PMID: 8959021Oct 31, 1996Paper

Functional changes in neuronal systems induced by phencyclidine administration

Annals of the New York Academy of Sciences
T NabeshimaY Noda

Abstract

To analyze the mechanisms of PCP abuse, we investigated the changes in PCP-induced motivational properties and neuronal functions in animals. First, we determined that PCP-induced withdrawal syndrome may, in part, be produced by 5-HTergic neuronal systems. Second, using rats treated with subacute PCP, we established that subacute PCP may produce behavioral changes (stereotyped behaviors and hyperlocomotion), mediated by both dopaminergic, 5-HTergic neuronal, and NO systems. Third, using the place conditioning paradigm, we confirmed that (1) both dopamine-D1 and 5-HT2A receptors, but not sigma receptors, may be involved in PCP-induced place aversion, and (2) subacute PCP produces place preference. Finally, we demonstrated that subacute PCP may produce neurochemical changes (the number of 5-HT2A receptors, dopamine turnover, NO synthesis, and immediate early gene expression). These results suggested that several neuronal changes may be related to behavioral changes induced by subacute PCP. Furthermore, it is hypothesized that the alternations of several neuronal systems may establish PCP abuse via the changes of the immediate early gene expression and NO activity induced by subacute PCP treatment. Further studies using receptor s...Continue Reading

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Citations

Nov 18, 2000·Behavioural Brain Research·Y MiyamotoT Nabeshima
Jun 6, 2007·Neuroscience Letters·Tomotaka MurotaniAtsushi Yamatodani
Oct 10, 2015·European Journal of Pharmacology·Chrislean Jun BotanasJae Hoon Cheong
Apr 18, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Cecile Spielewoy, Athina Markou
Jul 10, 2002·Annals of the New York Academy of Sciences·K ToyookaY Takahashi
Nov 21, 2000·Annals of the New York Academy of Sciences·N TomitaY Takahashi

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