PMID: 590882Jan 1, 1977

Functional changes in the caudate and accumbens nuclei during amygdaloid and hippocampal seizure development in kindled cats

Folia Psychiatrica Et Neurologica Japonica
M Sato

Abstract

Electroencephalographic changes were examined in the caudate nucleus and accumbens nucleus during limbic seizure development in eight kindled cat preparations. The emergence of self-sustained after-discharge and interictal discharge was demonstrated in the accumbens nucleus during limbic seizure development. This finding suggests secondary epileptogenic functional alterations in the mesolimbic dopamine neuron systems. Moreover, the epileptiform responses triggered from the accumbens and caudate nuclei increased markedly with progressive limbic seizure development. These results suggest that a limbic seizure could produce a secondary functional reorganization of the brain dopaminergic neuron systems, especially of the mesolimbic dopamine neuron systems that has been reported to play an important role in the manifestation of psychotic symptom.

References

Nov 1, 1975·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·R J RacineJ Zaide
Nov 1, 1975·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·G V Goddard, R M Douglas
Nov 1, 1975·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·M Sato, T Nakashima
Mar 1, 1972·Electroencephalography and Clinical Neurophysiology·R J Racine
Aug 1, 1973·Archives of General Psychiatry·J R Stevens
Jan 1, 1974·Journal of Psychiatric Research·N E Andén
Nov 1, 1969·Experimental Neurology·G V GoddardC K Leech

Citations

Feb 26, 1998·Epilepsy Research·K Hamada, J A Wada
Nov 1, 1978·Journal of Neurology, Neurosurgery, and Psychiatry·J R Stevens
Oct 9, 2002·Fukushima Journal of Medical Science·Yasuhito YamadaShin-ichi Niwa
Dec 12, 2012·Neuroscience and Biobehavioral Reviews·Eric P Zorrilla, George F Koob

Related Concepts

Amygdaloid Structure
Felis catus
Caudate Nucleus Structure
Electric Stimulation Technique
Electroencephalogram
Paleostriatum
Structure of Subiculum Hippocampi
Nucleus Accumbens
Non-epileptic Convulsion
Septofimbrial Nucleus

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