Functional changes in the frontal cortex in Parkinson's disease using a rat model

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
Zhongyu HouShuwei Liu

Abstract

In recent years, investigations of the pathologic mechanism of Parkinson's disease (PD) have mainly concentrated on the basal ganglia. However, recent studies have confirmed that pathological changes in PD are accompanied by functional motor changes of the cerebral cortex. Rats were injected with 6-hydroxydopamine and ascorbic acid in the right substantia nigra. In this rat model of PD, magnetic resonance spectroscopy showed the ratio of N-acetyl-aspartic acid to creatine in a lesion in the right frontal cortex was significantly lower than the same ratio in a control group of rats. The ratio of choline to creatine in a lesion in the right frontal cortex was not significantly different between the PD-model rats and control rats. In addition, the optical densities of neurofilament protein and synaptophysin positive sites decreased significantly on the side of the brain with the injury compared with the side without the injury, and with both sides in the control rats. The density of synapses in the frontal cortex on the lesioned side was decreased compared with the unlesioned side. There were abnormal changes in the presynaptic membrane, postsynaptic membrane and synaptic vesicles, and the typical synaptic structure was no longer ...Continue Reading

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Citations

Aug 23, 2011·In Vitro Cellular & Developmental Biology. Animal·Shabnam BakhshalizadehMojtaba Saedi
Jun 9, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Songye LiYiyun Huang
Nov 15, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Antonio CerasaAldo Quattrone
Mar 9, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Antonio CerasaAldo Quattrone
Jan 9, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Songye LiYiyun Huang
May 21, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Hayel TuncelSandeep Sv Golla

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