Functional changes in the human auditory cortex in ageing

PloS One
Oliver ProfantJosef Syka

Abstract

Hearing loss, presbycusis, is one of the most common sensory declines in the ageing population. Presbycusis is characterised by a deterioration in the processing of temporal sound features as well as a decline in speech perception, thus indicating a possible central component. With the aim to explore the central component of presbycusis, we studied the function of the auditory cortex by functional MRI in two groups of elderly subjects (>65 years) and compared the results with young subjects (<lt;30 years). The elderly group with expressed presbycusis (EP) differed from the elderly group with mild presbycusis (MP) in hearing thresholds measured by pure tone audiometry, presence and amplitudes of transient otoacoustic emissions (TEOAE) and distortion-product oto-acoustic emissions (DPOAE), as well as in speech-understanding under noisy conditions. Acoustically evoked activity (pink noise centered around 350 Hz, 700 Hz, 1.5 kHz, 3 kHz, 8 kHz), recorded by BOLD fMRI from an area centered on Heschl's gyrus, was used to determine age-related changes at the level of the auditory cortex. The fMRI showed only minimal activation in response to the 8 kHz stimulation, despite the fact that all subjects heard the stimulus. Both elderly grou...Continue Reading

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Citations

Apr 16, 2016·Psychophysiology·Bernhard Ross, Takako Fujioka
Jan 30, 2015·Cell and Tissue Research·Ladislav OudaJosef Syka
Jun 1, 2016·Frontiers in Neuroscience·Velia Cardin
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Mar 14, 2019·Frontiers in Aging Neuroscience·Oliver ProfantJosef Syka
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Mar 30, 2018·Frontiers in Behavioral Neuroscience·Yu-Chen ChenJian-Ping Gu
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Aug 31, 2021·Frontiers in Cell and Developmental Biology·Siyu LiXia Gao

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