Functional Changes of Dendritic Cells in C6 Glioma-Bearing Rats That Underwent Combined Argon-Helium Cryotherapy and IL-12 Treatment

Technology in Cancer Research & Treatment
Ming LiXiwen Shi

Abstract

The aim of this study was to explore changes in tumor tissues of glioma-bearing rats that underwent argon-helium cryoablation as well as changes in antitumor immunity before and after combined interleukin 12 treatment. Two hundred sixty Wistar rats were randomly divided into a blank control group, intravenous injection interleukin-12 group, cryotherapy group, and cryotherapy + intravenous injection group. C6 glioma cells proliferated in vitro were implanted subcutaneously on the backs of rats to establish C6 glioma-bearing animal models. Each group underwent the corresponding treatments, and morphological changes in tumor tissues were examined using hematoxylin-eosin staining. CD11c staining was examined using immunohistochemistry, and differences in dendritic cells and T-cell subsets before and after treatment were analyzed using flow cytometry. The control group showed no statistical changes in terms of tumor tissue morphology and cellular immunity, cryotherapy group, and cryotherapy + intravenous injection group, among which the count for the cryotherapy + intravenous injection group was significantly higher than those of all other groups. In the argon-helium cryotherapy group, tumor cells were damaged and dendritic cell mar...Continue Reading

References

Mar 11, 1998·Seminars in Surgical Oncology·G G Hamad, J P Neifeld
Mar 17, 2005·Breast Cancer Research and Treatment·Michael S SabelAlfred E Chang
Jan 20, 2010·Technology in Cancer Research & Treatment·Ming LiLi Miao
Jan 11, 2011·Technology in Cancer Research & Treatment·M LiY Q Cai
Mar 11, 2015·Cancer Immunology, Immunotherapy : CII·Sean G SmithDavid A Zaharoff
Apr 4, 2015·Journal of Immunotherapy·Lingbing ZhangJeffrey A Norton

❮ Previous
Next ❯

Citations

Apr 13, 2018·Frontiers in Oncology·Joe AbdoDevendra K Agrawal
Aug 8, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xiaoli WuJin Chang
Jun 28, 2017·World Journal of Gastroenterology : WJG·Qiao-Huan YanYing-Gang Lv
Sep 14, 2020·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·Zheng ZhengSujing Zhang

❮ Previous
Next ❯

Methods Mentioned

BETA
flow cytometry

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Transactions of the Ophthalmological Societies of the United Kingdom
G E Hewson
The Medical Journal of Australia
E J Milverton, A B Hunyor
Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
J G Bellows
Voprosy kurortologii, fizioterapii, i lechebnoĭ fizicheskoĭ kultury
V D Grigor'eva, D V Suzdal'nitskiĭ
© 2021 Meta ULC. All rights reserved