Functional changes of monocytes due to dialysis membranes

Kidney International
D RoccatelloA Amore

Abstract

The functional effects directly induced by dialysis membranes on peripheral monocytes were analyzed in a plasma-free model of simulated dialysis using Cuprophan, cuprammonium rayon, polyacrylonitrile, polymethylmetacrilate and polysulphone membranes. A severe reduction of monocyte phagocytosis of IgG-coated erythrocytes was found by using Cuprophan and cuproammonium rayon. The cytofluorimetric analysis of several cell surface receptors, involved in the immune phagocytosis and recognizable by five quoted monoclonal antibodies, did not reveal any significant change. The defective phagocytosis of the IgG-coated erythrocytes by monocytes, due to the exposure to cellulose-derived membranes, was paralleled by an impaired interiorization of heat-aggregated human immunoglobulins, as analyzed by electron microscopy. The cell membrane binding of aggregated immunoglobulins was found to be unaffected. The defect was associated to a remarkably depressed generation of reactive oxygen species after Zymosan stimulation. Therefore, the defective immune phagocytosis induced by exposure of monocytes to cellulosic membranes was not due to a receptor rearrangement or an impaired binding of ingestible particles, but to a reduced internalization capa...Continue Reading

References

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Citations

Dec 1, 1994·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J M Lazarus, W F Owen
Mar 1, 1996·Kidney International·S HeidenreichB Harrach
Sep 1, 1993·Kidney International·R M Hakim
Jul 1, 1993·Kidney International·R VanholderS M Ringoir
May 1, 1993·Kidney International·D RoccatelloG Piccoli
Dec 10, 1991·Clinical Materials·R Vanholder
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Related Concepts

Cell Survival
Renal Dialysis Machine
Nongranular Leukocyte
Membranes, Artificial
Electron Microscopy
Phagocytosis
Fc Receptor

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