Functional changes of monocytes due to dialysis membranes

Kidney International
D RoccatelloA Amore


The functional effects directly induced by dialysis membranes on peripheral monocytes were analyzed in a plasma-free model of simulated dialysis using Cuprophan, cuprammonium rayon, polyacrylonitrile, polymethylmetacrilate and polysulphone membranes. A severe reduction of monocyte phagocytosis of IgG-coated erythrocytes was found by using Cuprophan and cuproammonium rayon. The cytofluorimetric analysis of several cell surface receptors, involved in the immune phagocytosis and recognizable by five quoted monoclonal antibodies, did not reveal any significant change. The defective phagocytosis of the IgG-coated erythrocytes by monocytes, due to the exposure to cellulose-derived membranes, was paralleled by an impaired interiorization of heat-aggregated human immunoglobulins, as analyzed by electron microscopy. The cell membrane binding of aggregated immunoglobulins was found to be unaffected. The defect was associated to a remarkably depressed generation of reactive oxygen species after Zymosan stimulation. Therefore, the defective immune phagocytosis induced by exposure of monocytes to cellulosic membranes was not due to a receptor rearrangement or an impaired binding of ingestible particles, but to a reduced internalization capa...Continue Reading


Oct 20, 1977·The New England Journal of Medicine·N M AurigemmaE G Lowrie
Jan 1, 1976·International Archives of Allergy and Applied Immunology·J McIntoshR Penny
Jan 1, 1977·Transactions - American Society for Artificial Internal Organs·W F KeaneL Raij
Jan 1, 1985·Clinical Immunology and Immunopathology·R PhillipsA R Rabson
May 1, 1987·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S L Lewis, D E Van Epps
Feb 21, 1985·The New England Journal of Medicine·M A ArnaoutH R Colten
Mar 25, 1968·JAMA : the Journal of the American Medical Association·L S Kaplow, J A Goffinet
Aug 1, 1983·Kidney International·E A MichelsonA Kulczycki
May 1, 1982·Scandinavian Journal of Clinical and Laboratory Investigation·L V Jepsen, T Skottun


Dec 1, 1994·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J M Lazarus, W F Owen
Mar 1, 1996·Kidney International·S HeidenreichB Harrach
Sep 1, 1993·Kidney International·R M Hakim
Jul 1, 1993·Kidney International·R VanholderS M Ringoir
May 1, 1993·Kidney International·D RoccatelloG Piccoli
Dec 10, 1991·Clinical Materials·R Vanholder
Oct 21, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Y Le MeurV Praloran
Oct 29, 2000·Journal of the American Society of Nephrology : JASN·V S BalakrishnanB J Pereira

Related Concepts

Cell Survival
Renal Dialysis Machine
Nongranular Leukocyte
Membranes, Artificial
Electron Microscopy
Fc Receptor

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Laryngeal Neoplasms

Laryngeal Neoplasms occur in the Larynx and are typically associated with smoking and alcohol consumption. Discover the latest research on Laryngeal Neoplasms here.

Cell Atlas Along the Gut-Brain Axis

Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here.