PMID: 9007617Jan 1, 1996Paper

Functional characteristics of cord blood T lymphocytes after lectin and anti-CD3 stimulation. Differences in the way T cells express activation molecules and proliferate

International Journal of Clinical & Laboratory Research
G LuciveroD Mancino

Abstract

Newborns are more susceptible than adults to infections, which suggests a relative immaturity of the immune system early after birth. Cord blood T cells differ significantly both in surface phenotype and function from adult T cells. We examined the proliferation and expression of activation molecules by lymphocytes isolated from umbilical cord blood or peripheral blood of adults. The lymphocytes were cultured for 5 days in the presence of phytohemagglutinin, concanavalin A, or anti-CD3 monoclonal antibody. Cord blood T cells expressed the CD45RA molecule, while a low proportion expressed the RO isoform, a marker of primed or activated lymphocytes. Furthermore, more than 95% of neonatal lymphocytes bear the CD38 molecule, but do not express the CD57 molecule. After stimulation by phytohemagglutinin or concanavalin A, the lymphocytes from newborns were activated and proliferated as efficiently as adult T cells. Anti-CD3 did not cause neonatal lymphocytes to proliferate, but these cells expressed activation molecules, such as HLA-DR antigens and the receptor for interleukin-2 and transferrin. The relevance of these findings to tolerance induction in immature cord blood T cells is discussed.

References

Sep 1, 1976·Clinical Immunology and Immunopathology·C GranbergP Toivanen
Nov 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·D T HarrisE A Boyse
Jun 1, 1989·Clinical Immunology and Immunopathology·L M BradleyS M Shiigi
Apr 1, 1983·British Journal of Haematology·R GerliF Spinozzi
Sep 1, 1983·The Journal of Experimental Medicine·S C MeuerE L Reinherz
Mar 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·E L ReinherzS F Schlossman
Aug 1, 1995·The Journal of Clinical Investigation·K MigitaS Nagataki

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Citations

Aug 30, 2003·Cytokine·Katarzyna Bogunia-KubikShara B A Cohen
Oct 3, 2001·Clinical Immunology : the Official Journal of the Clinical Immunology Society·J TekstraR H Beelen
Aug 6, 2005·Cytotherapy·W Tse, Mj Laughlin
Jul 9, 2005·Transplantation·Yukiko KishiUNKNOWN Tokyo Stem Cell Transplant Consortium

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