Functional characteristics of nonischemic region during pacing-induced myocardial ischemia in angina pectoris

The American Journal of Cardiology
K YamanishiA Ohno

Abstract

To investigate the details of the hyperfunction of nonischemic area during acute ischemia, the regional myocardial function at rest and immediately after rapid cardiac pacing was compared using cineventriculography in 12 patients with stable effort angina. Three left ventricular boundaries at the time of end-diastole, aortic valve opening and end-systole were superimposed, and 128 radial grids were drawn from the center of gravity of end-diastolic frame to the endocardial margin. The changes in the length of each radial grid provided quantitative description of segmental systolic function. In the ischemic area, the percent of total segment shortening decreased from 36 +/- 6% (mean +/- standard error of the mean) to 24 +/- 8% (p less than 0.05) in patients with a significant narrowing of left anterior descending coronary artery (LAD), and from 42 +/- 6% to 20 +/- 4% (p less than 0.05) in those with right coronary artery (RCA) involvement. In the nonischemic area, the percent of total segment shortening increased from 33 +/- 7% to 44 +/- 7% (p less than 0.05) in LAD disease, while it was unchanged in RCA involvement (40 +/- 5% vs 41 +/- 7%). The percentage of isovolumic segment shortening increased from 1 +/- 4% to 7 +/- 3% (p le...Continue Reading

References

Nov 1, 1969·Circulation Research·J V TybergE H Sonnenblick
Aug 1, 1984·Journal of the American College of Cardiology·S SasayamaM Kuwahara
Jan 1, 1983·The American Journal of Cardiology·M MolaugF Kiil

Citations

Jan 1, 1993·Journal of the American College of Cardiology·M FujitaS Sasayama
Mar 15, 1997·Journal of the American College of Cardiology·S PerliniP Foëx
May 1, 1995·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·T MorozumiT Nishimura

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.