PMID: 8947459Nov 15, 1996Paper

Functional characterization by heterologous expression of a novel cloned tachykinin peptide receptor

The Biochemical Journal
L F DonaldsonM R Hanley

Abstract

An orphan receptor resembling the neurokinin 3 tachykinin receptor (NK3), initially claimed to be an atypical opioid receptor, is shown herein to respond potently to the physiological NK3 receptor ligand, neurokinin B. This 'NK4' receptor did not give functional responses in Xenopus oocytes to opioid agonists. However, NK4 receptor activation was inhibited by nanomolar concentrations of dynorphin. The NK4 receptor is therefore a tachykinin receptor which is functionally antagonized by an endogenous opioid peptide.

Citations

Jul 5, 2005·Expert Opinion on Investigational Drugs·P GeppettiC Bertrand
Mar 7, 1998·British Journal of Pharmacology·J MagranerM L Candenas
Apr 11, 2014·Disease Markers·Crislaine Aparecida da SilvaJuliana Reis Machado
Aug 8, 2014·BioMed Research International·Giuseppe LucarelliPasquale Ditonno
Feb 3, 2018·BioMed Research International·Blandina Bernal-MoralesCarlos M Contreras
Jan 16, 2010·Reproductive Biology and Endocrinology : RB&E·Nigel M Page
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Oct 12, 2016·Journal of Biosocial Science·Zbigniew CzaplaJanusz Piontek
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Jan 20, 2004·Life Sciences·Jocelyn N PennefatherCarlo Alberto Maggi

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