PMID: 8495246May 1, 1993

Functional characterization of muscarinic receptors in murine airways

British Journal of Pharmacology
J GarssenF P Nijkamp

Abstract

1. The effects of muscarinic receptor antagonists considered to be selective for M1 receptors (pirenzepine; PZ), M2 receptors (AFDX-116), and for M3 receptors (4-diphenyl acetoxy N-methyl-piperidine (4-DAMP)) were used to investigate the existence of muscarinic receptors subtypes in murine airways. Atropine was used as a nonselective antagonist. The effects of these antagonists were studied upon tracheal contractions induced either by EFS (electric field stimulation) or by application of an exogenous cholinoceptor agonist (arecoline). 2. The muscarinic receptor antagonists tested inhibited arecoline-induced tracheal contractions with the following rank order of potency: 4-DAMP = atropine > pirenzepine = AFDX-116. The rank order of potency of the muscarinic antagonists used in inhibiting EFS-induced tracheal contractions was: 4-DAMP = atropine > PZ > AFDX-116. The pA2 values for these antagonists were similar when compared to the pA2 values determined in guinea-pig and bovine airway smooth muscle. 3. In addition to in vitro studies, the effects of inhalation of the different muscarinic antagonists on lung function parameters in vivo were investigated. Inhalation of 4-DAMP induced a decrease in airway resistance and an increase i...Continue Reading

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Citations

Dec 17, 1991·European Journal of Pharmacology·A J Van OosterhoutF P Nijkamp
Nov 1, 1990·Journal of Pharmacological Methods·J GarssenF P Nijkamp
Mar 1, 1990·The American Review of Respiratory Disease·P A Minette, P J Barnes
Sep 1, 1990·British Journal of Pharmacology·P Aas, J Maclagan
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Related Concepts

Arecoline
Bronchial System
Piperidine
Inhalation of Drugs
Mice, Inbred BALB C
Lung
Cavia
Airway Resistance
Murine
Antagonist Muscle Action

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