PMID: 7535749Feb 1, 1995Paper

Functional characterization of rat chemokine macrophage inflammatory protein-2

Inflammation
C W FrevertL Kobzik

Abstract

Expression of mRNA for the C-X-C chemokine, macrophage inflammatory protein-2 (MIP-2), is induced during acute inflammation in rat models of disease. We have characterized the phlogistic potential of rat recombinant MIP-2 (rMIP-2) protein in vitro and in vivo. Recombinant MIP-2 caused marked PMN chemotaxis in vitro, with peak chemotactic activity at 10 nM. Incubation of whole blood with rMIP-2 caused a significant loss of L-selectin and a significant increase in Mac-1 expression on the PMN surface. Under similar conditions rMIP-2 also caused a modest respiratory burst in PMNs. The intratracheal instillation of 10 and 50 micrograms of rMIP-2 caused a significant influx of PMNs into the airspace of the lungs. Rat MIP-2 is a potent neutrophil chemotactic factor capable of causing neutrophil activation and is likely to function in PMN recruitment during acute inflammation in rat disease models.

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Jun 3, 1991·Journal of Immunological Methods·G E FreemanP M Brooks
Sep 1, 1990·The Journal of Experimental Medicine·P Tekamp-OlsonA Cerami
Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S D WolpeA Cerami
Feb 1, 1994·American Journal of Respiratory Cell and Molecular Biology·C E RoseS M Fu

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Citations

Feb 14, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A B LentschM J Edwards
Oct 13, 2000·Journal of the American College of Surgeons·G Martinez-MierP A Ward
Jun 15, 2001·ILAR Journal·Boris J. CzermakPeter A. Ward
Feb 1, 2002·Alcoholism, Clinical and Experimental Research·Ping ZhangSteve Nelson
Jul 12, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·John B ZamjahnGregory J Bagby
Sep 18, 2004·American Journal of Respiratory and Critical Care Medicine·Hiroshi UenoAkitoshi Ishizaka
Jun 7, 2008·American Journal of Respiratory and Critical Care Medicine·Haiying ZhangAkitoshi Ishizaka
Apr 1, 1999·American Journal of Respiratory Cell and Molecular Biology·J G WagnerR A Roth
Oct 25, 2002·American Journal of Respiratory Cell and Molecular Biology·Joseph P MizgerdClaire M Doerschuk
Jun 28, 2003·American Journal of Respiratory Cell and Molecular Biology·Jeff N VanderbiltLeland G Dobbs
Mar 22, 2005·American Journal of Respiratory Cell and Molecular Biology·Samithamby JeyaseelanG Scott Worthen
Aug 2, 2005·American Journal of Respiratory Cell and Molecular Biology·Kahoru NishinaRobert J Mason
Sep 1, 2009·American Journal of Respiratory Cell and Molecular Biology·Anna HogmalmKristina Bry
Aug 2, 2000·Critical Care Medicine·T P ShanleyP R Knight
Jul 29, 1999·Chest·R M StrieterT J Standiford
Aug 17, 2005·Journal of Vascular Surgery·Hong T HuaMichael T Watkins
Oct 13, 2015·European Journal of Pharmacology·Shingo KubotaHiromasa Inoue
Jul 28, 2005·Alcoholism, Clinical and Experimental Research·Lee J QuintonGregory J Bagby
May 1, 1999·Toxicology and Applied Pharmacology·G M GrabowskiJ J Godleski
Apr 30, 2002·Seminars in Immunology·Joseph P Mizgerd
Aug 11, 2005·Respiratory Research·Carine Delayre-OrthezFrançoise Pons
Mar 17, 1997·Biochemical and Biophysical Research Communications·K MurakamiT Kondo
Nov 16, 2001·Toxicology and Applied Pharmacology·T M RiceJ D Paulauskis
Aug 18, 2000·The Journal of Surgical Research·G Martinez-MierP A Ward
Sep 14, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Richard A JohnstonStephanie A Shore

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