Functional characterization of spikelet activity in the primary visual cortex

The Journal of Physiology
Benjamin SchollNicholas J Priebe

Abstract

In vivo whole-cell patch-clamp recordings in cat visual cortex revealed small deflections in the membrane potential of neurons, termed spikelets. Spikelet statistics and functional properties suggest these deflections originate from a single, nearby cell. Spikelets shared a number sensory selectivities with the principal neuron including orientation selectivity, receptive field location and eye preference. Principal neurons and spikelets did not, however, generally share preferences for depth (binocular disparity). Cross-correlation of spikelet activity and membrane potential revealed direct effects on the membrane potential of some principal neurons, suggesting that these cells were synaptically coupled or received common input from the cortical network. Other spikelet-neuron pairs revealed indirect effects, likely to be the result of correlated network events. Intracellular recordings in the neocortex reveal not only the membrane potential of neurons, but small unipolar or bipolar deflections that are termed spikelets. Spikelets have been proposed to originate from various sources, including active dendritic mechanisms, gap junctions and extracellular signals. Here we examined the functional characteristics of spikelets measu...Continue Reading

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Oct 25, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Benjamin SchollNicholas J Priebe

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Citations

Aug 23, 2019·Reviews in the Neurosciences·Martina MichalikovaRichard Kempter
Feb 16, 2018·Scientific Reports·Friederice PirschelJutta Kretzberg

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