Functional characterization of the Candida albicans homologue of secretion-associated and Ras-related (Sar1) protein

Yeast
Linghuo JiangShi-Hsiang Shen

Abstract

Secretion-associated and Ras-related protein (Sar1p) plays an essential role during the protein transport from the endoplasmic reticulum to the Golgi apparatus. The cDNA sequence of the Sar1 gene has been identified and characterized from the human yeast pathogen, Candida albicans. This cDNA encodes a protein of 190 amino acids, which shares a 78% sequence identity with Saccharomyces cerevisiae Sar1p and contains the conserved GTP-binding motifs of the small GTPase superfamily. Complementation studies confirmed that this cDNA encodes the functional homologue of ScSar1p. The recombinant C. albicans Sar1p exhibits GTP-binding activity in vitro that was abolished by deletion of one of the three GTP-binding motifs.

References

Jan 1, 1992·Annual Review of Biochemistry·S Clarke
Jan 1, 1991·Annual Review of Microbiology·J E Cutler
Mar 1, 1995·Infection and Immunity·H KaminishiY Hagihara
May 16, 1998·The Journal of Cell Biology·M AridorW E Balch
Apr 29, 2000·Trends in Microbiology·F C Odds
Mar 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·K W TzungN Agabian

❮ Previous
Next ❯

Citations

Feb 12, 2009·Mycoses·William A Fonzi
Jul 12, 2002·Yeast
Feb 28, 2020·Journal of Fungi·Christiane RollenhagenSamuel A Lee
Apr 29, 2008·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Ying WanLinghuo Jiang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.