Functional chemotactic factor CP-10 and MRP-14 are abundant in murine abscesses.

Infection and Immunity
M KocherL Geczy C

Abstract

Murine abscesses induced by intraperitoneal injection of a mixture of Escherichia coli, Bacteroides fragilis, and bran are established models for the study of localized infectious and inflammatory lesions. Chemotactic factors are though to mediate the directed migration of large numbers of leukocytes into the abscess. Microorganisms located within the encapsulated lesion are not readily eliminated by the leukocytes, but their numbers are controlled over many weeks. We report the presence of large amounts of two murine S100 proteins, CP-10 and migration inhibition factor-related protein 14 (MRP-14), in abscesses as demonstrated by immunohistochemistry and measured by enzyme-linked immunosorbent assay and Western blotting (immunoblotting). High levels of CP-10 (7.7 +/- 1 mg/ml) and MRP-14 (5.5 +/- 1 mg/ml) were found throughout the time course of abscess development from early acute-phase lesions, which are predominantly neutrophilic, to late chronic-phase lesions, which contained more mononuclear cells. Approximately one-third of these amounts occurred as monomers (2.0 mg/ml for MRP 14 and 2.2 mg/ml for CP-10). Abscess fluid was strongly chemotactic, and a portion of the activity was due to CP-10, indicating its important role i...Continue Reading

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Citations

Mar 20, 1999·The Journal of Biological Chemistry·C A HarrisonC L Geczy
May 9, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·K XuC L Geczy
Aug 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Karen VandalPhilippe A Tessier
Mar 23, 2006·Infection and Immunity·Ruth R MontgomeryStephen E Malawista
Nov 9, 2006·Experimental Lung Research·Markus O HenkeJa Seok Koo
Feb 10, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yasumi EndohKenneth Hsu
Apr 26, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·K Xu, C L Geczy
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May 31, 2019·Inorganic Chemistry·Rose C HadleyElizabeth M Nolan
Feb 5, 2008·American Journal of Obstetrics and Gynecology·Elin ØdegaardAnne Cathrine Staff

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