Functional cloning of ICAM-2, a cell adhesion ligand for LFA-1 homologous to ICAM-1

Nature
D E StauntonT A Springer

Abstract

The leukocyte adhesion molecule LFA-1 mediates a wide range of lymphocyte, monocyte, natural killer cell, and granulocyte interactions with other cells in immunity and inflammation. LFA-1 (CD11a/CD18) is a receptor for intercellular adhesion molecule 1 (ICAM-1, CD54), a surface molecule which is constitutively expressed on some tissues and induced on other in inflammation. Induction of ICAM-1 on epithelial cells, endothelial cells and fibroblasts mediates LFA-1-dependent adhesion of lymphocytes. Several lines of evidence have suggested the existence of a second LFA-1 ligand: homotypic adhesion of one cell line was inhibited by a monoclonal antibody to LFA-1, but not by one to ICAM-1; there exists an LFA-1-dependent, ICAM-1-independent pathway of adhesion to endothelial cells; and also, there are some types of target cells in which LFA-1-dependent T-lymphocyte adhesion and lysis are independent of ICAM-1. We have cloned this second ligand, designated ICAM-2, using a novel method for identifying ligands of adhesion molecules. ICAM-2 is an integral membrane protein with two immunoglobulin-like domains, whereas ICAM-1 has five. Remarkably, ICAM-2 is much more closely related to the two most N-terminal domains of ICAM-1 (34% identit...Continue Reading

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
May 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·B Seed, A Aruffo
Mar 10, 1989·Cell·J M GreveA McClelland
Oct 23, 1987·Science·E Ruoslahti, M D Pierschbacher
Jul 1, 1988·Immunology Today·M L DustinT A Springer
Jun 11, 1986·Nucleic Acids Research·G von Heijne
Jun 14, 1967·Journal of Molecular Biology·B Hirt
Jan 1, 1983·Methods in Enzymology·M O DayhoffL T Hunt
Jul 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·D DavignonT A Springer
May 5, 1982·Journal of Molecular Biology·J Kyte, R F Doolittle

❮ Previous
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Citations

May 6, 1999·European Journal of Immunology·F A SymonA J Wardlaw
May 16, 2001·Arthritis and Rheumatism·R A Carter, I P Wicks
Sep 1, 1990·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·M L Dustin
Dec 1, 1990·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·S Dedhar
Jun 5, 2008·Inflammatory Bowel Diseases·Jesús Rivera-NievesKlaus Ley
Jul 13, 2002·International Journal of Cancer. Journal International Du Cancer·Yukinobu MaruoKunzo Orita
Oct 1, 1993·Journal of Cellular Biochemistry·E Papakonstantinou, G N Misevic
Jan 1, 1991·Journal of Clinical Laboratory Analysis·J A ThompsonW Zimmermann
Mar 1, 1994·Medicinal Research Reviews·D CoxK Yoshida
May 1, 1991·Cancer Metastasis Reviews·E Roos
Feb 1, 1990·Cancer Metastasis Reviews·P N Belloni, R J Tressler
Jul 1, 1991·Journal of Clinical Immunology·L M VossP J Leibson
Jun 1, 1993·Inflammation·R S Shames, E J Goetzl
Jun 1, 1993·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·M VorkaufW Sterry
Jul 19, 1995·Molecular and Cellular Biochemistry·R P Menon, P R Sudhakaran
Nov 1, 1992·The Histochemical Journal·M A Kerr, S C Stocks
Jan 1, 1993·Virchows Archiv. A, Pathological Anatomy and Histopathology·C G TortosaE G Olivares
Jan 1, 1991·Cancer Immunology, Immunotherapy : CII·R L BolhuisE Braakman
Jan 1, 1993·Cancer Immunology, Immunotherapy : CII·T TakahashiT Yoshiki
Apr 28, 1995·Biochimica Et Biophysica Acta·A M Scanu, C Edelstein
Jan 1, 1996·Life Sciences·I R Williams, T S Kupper
Jan 1, 1990·Molecular Aspects of Medicine·A Shock, G J Laurent
Aug 1, 1991·Molecular Immunology·N AuphanA M Schmitt-Verhulst
Jan 1, 1994·Pharmacology & Therapeutics·P Sargeant, S O Sage
Aug 1, 1992·Trends in Neurosciences·D J SloanH M Charlton
May 7, 1992·Biochimica Et Biophysica Acta·Y KitaT Horiuchi
Mar 14, 1995·Biochimica Et Biophysica Acta·S MartinottiA C Hayday
Sep 13, 1993·Biochimica Et Biophysica Acta·T KurachiS Murota

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