PMID: 8586264Dec 15, 1995Paper

Functional cloning of the dihydropteroate synthase gene of Staphylococcus haemolyticus

FEMS Microbiology Letters
P KellamC J Delves

Abstract

A 1,7-kilobase fragment of the Staphylococcus haemolyticus chromosome containing the dihydropteroate synthase gene has been cloned by complementation in a temperature-sensitive mutant of Escherichia coli. The gene, designated folP, predicts a gene product of 29613 Da which shares significant amino acid sequence identity with other known bacterial dihydropteroate synthases. Analysis of the DNA sequence upstream and downstream of folP identified two further, incomplete open reading frames, one of which shows predicted amino acid sequence similarity to a second bacterial folic acid synthesis enzyme, dihydroneopterin aldolase.

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Jan 11, 1984·Nucleic Acids Research·J DevereuxO Smithies
Jan 1, 1994·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·N OgasawaraH Yoshikawa

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Citations

Jun 1, 2007·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Michelle Wright ValderasWilliam W Barrow
May 19, 2000·Antimicrobial Agents and Chemotherapy·D L WilliamsT P Gillis
Apr 25, 1997·Journal of Molecular Biology·I C HampeleR L Then
Aug 11, 2001·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Ola Sköld

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