Functional complexity and regulation through RNA dynamics.

Nature
Elizabeth A DethoffHashim M Al-Hashimi

Abstract

Changes to the conformation of coding and non-coding RNAs form the basis of elements of genetic regulation and provide an important source of complexity, which drives many of the fundamental processes of life. Although the structure of RNA is highly flexible, the underlying dynamics of RNA are robust and are limited to transitions between the few conformations that preserve favourable base-pairing and stacking interactions. The mechanisms by which cellular processes harness the intrinsic dynamic behaviour of RNA and use it within functionally productive pathways are complex. The versatile functions and ease by which it is integrated into a wide variety of genetic circuits and biochemical pathways suggests there is a general and fundamental role for RNA dynamics in cellular processes.

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Citations

Oct 31, 2013·Journal of Biomolecular NMR·Konstantin BerlinDavid Fushman
Aug 31, 2013·Analytical Chemistry·Janghyun LeeHashim M Al-Hashimi
Nov 21, 2012·Journal of the American Chemical Society·Daud I ColeMichael B Jarstfer
Oct 8, 2013·Journal of the American Chemical Society·Konstantin BerlinDavid Fushman
Oct 9, 2012·Nature·Elizabeth A DethoffHashim M Al-Hashimi
Feb 15, 2013·Genome Biology and Evolution·Yuanhui MaoShiheng Tao
Jan 8, 2013·Nucleic Acids Research·Svetlana A ShabalinaAnna Kashina
Aug 2, 2012·Journal of Bioinformatics and Computational Biology·Frank Eisenhaber
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Jan 25, 2014·Nucleic Acids Research·Yi-Ju WuJin-Der Wen
Dec 25, 2013·Annual Review of Physical Chemistry·Loïc SalmonHashim M Al-Hashimi
Mar 13, 2014·Annual Review of Biochemistry·Anthony M MustoeHashim M Al-Hashimi
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Aug 28, 2014·Nature Communications·Cristina MilittiFátima Gebauer
Sep 11, 2014·Proceedings of the National Academy of Sciences of the United States of America·Philip J HomanKevin M Weeks
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Jul 2, 2014·Nucleic Acids Research·Isabelle LebarsBruno Kieffer
Sep 5, 2014·Journal of Biomolecular NMR·Bharathwaj SathyamoorthyHashim Al-Hashimi
Feb 18, 2016·Nature Chemical Biology·Yun-Xing Wang
Jan 5, 2016·Nature Chemical Biology·Xuesong ShiDaniel Herschlag
Dec 25, 2015·Proceedings of the National Academy of Sciences of the United States of America·Xiaojun XuShi-Jie Chen
Jul 1, 2014·Proceedings of the National Academy of Sciences of the United States of America·Janghyun LeeHashim M Al-Hashimi
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