Functional Compromise Cohort Study (FCCS): Sarcopenia is a Strong Predictor of Mortality in the Intensive Care Unit

World Journal of Surgery
P A de HoogtJan H M B Stoot

Abstract

Functional compromise in elderly patients is considered to be a significant contributing factor in increased postoperative morbidity and mortality. It is described as a state of reduced physiologic reserves including, e.g., sarcopenia, cachexia, malnutrition and frailty with increased susceptibility to adverse health outcomes. Aim of this study was to investigate the association of sarcopenia with mortality in ICU patients. A retrospective analysis of a total of 687 patients admitted to the ICU from January 2013 until December 2014 was performed. Indirect measurements of functional compromise in these patients were conducted. Sarcopenia was assessed using the L3 muscle index by using Osirix© on computed tomography scans. Groningen Frailty Indicator (GFI) and Short Nutritional Assessment Questionnaire (SNAQ) scores were extracted from the digital patient filing system and were used to assess frailty and nutritional status. These factors were analyzed using logistic regression analysis as predictor for in-hospital mortality and 6-month mortality, which was the primary endpoint along with other secondary outcome measures. Age was an independent predictor of in-hospital mortality, OR 1.043 (95% CI 1.030-1.057, p < 0.001). Analysis ...Continue Reading

References

Mar 17, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·L P FriedUNKNOWN Cardiovascular Health Study Collaborative Research Group
Jul 4, 2002·Journal of Critical Care·Albert W WuLaura Morlock
Nov 12, 2002·Mechanisms of Ageing and Development·Arnold B MitnitskiKenneth Rockwood
Oct 9, 2004·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Hanneke SchuurmansJoris P J Slaets
Feb 1, 2005·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·H M KruizengaM A E van Bokhorst-de van der Schueren
Dec 11, 2007·Archives of Gerontology and Geriatrics·Monidipa DasguptaMark Speechley
Apr 9, 2008·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·F NeelemaatM A E van Bokhorst-de van der Schueren
Apr 16, 2010·Age and Ageing·Alfonso J Cruz-JentoftUNKNOWN European Working Group on Sarcopenia in Older People
Oct 29, 2011·Journal of Critical Care·Antonio Paulo NassarCarlos Augusto Dias
Oct 2, 2012·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Simon A W G DelloCornelis H C Dejong
Jan 31, 2013·Interactive Cardiovascular and Thoracic Surgery·Vladimir V LomivorotovAlexander M Karaskov
Mar 27, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lisa MartinVickie E Baracos
Apr 30, 2013·Critical Care : the Official Journal of the Critical Care Forum·Jack E ZimmermanWilliam A Knaus
Sep 3, 2013·Current Opinion in Critical Care·Sean M Bagshaw, Robert C McDermid
Jan 15, 2014·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Juul J W TegelsJ H M B Stoot

❮ Previous
Next ❯

Citations

Feb 11, 2018·World Journal of Surgery·Wilhelmus G P M LooijaardHeleen M Oudemans-van Straaten
May 31, 2018·Current Opinion in Critical Care·Wilhelmus G P M LooijaardPeter J M Weijs
Dec 13, 2019·Journal of Applied Physiology·Toby L ChambersScott Trappe
May 10, 2020·Anesthesia and Analgesia·Justin C De BiasioShahzad Shaefi
Aug 11, 2020·Seminars in Respiratory and Critical Care Medicine·Hans FlaattenBertrand Guidet
Jan 24, 2019·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Koeun LeeKyung Won Kim
Jun 4, 2020·Anaesthesia and Intensive Care·Patrick R JoyceChristopher Anstey
Jan 17, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Elisabeth De WaelePaul E Wischmeyer
Feb 2, 2021·Acute and Critical Care·Belgin Akan
Sep 26, 2020·Advances in Nutrition·Renata SilverioMarilia Seelaender
Aug 20, 2021·The Journal of Nutrition, Health & Aging·J UeshimaN Mori

❮ Previous
Next ❯

Software Mentioned

Osirix©
SPSS Statistics

Related Concepts

Related Feeds

Cardiac Cachexia

Cardiac cachexia is a syndrome associated with the progressive loss of muscle and fat mass. It most commonly affects patients with heart failure and can significantly decrease the quality of life and survival in these patients. Here is the latest research on cardiac cachexia.

Cachexia & Brown Fat

Cachexia is a condition associated with progressive weight loss due to severe illness. In cancer patients, it is proposed to occur as a result of tumor-induced energy wasting. Several proteins have been implicated in browning and depletion of white adipose tissue. Here is the latest research on cachexia and brown fat.