Functional Connectivity Abnormalities of Brain Regions With Structural Deficits in Primary Insomnia Patients

Frontiers in Neuroscience
Dongdong XieDahua Yu

Abstract

The present study examined the abnormal resting state functional connections (RSFCs) in structural deficit brain regions of primary insomnia (PI) patients. Thirty-three PI patients and 38 well-matched healthy controls participated in our study. We used voxel-based morphometry and RSFC to study functional connectivity abnormalities of brain regions with structural deficits in PI patients. PI patients showed decreased gray matter (GM) volume in the left dorsolateral prefrontal cortex, left orbitofrontal cortex (OFC), bilateral middle frontal gyrus (MFC), right inferior frontal gyrus (IFG), and left inferior temporal gyrus. Gray matter volume in the right MFC negatively correlated with Self-Rating Scale of Sleep (SRSS) scores, and GM volume in the right IFG negatively correlated with SRSS and Insomnia Severity Index (ISI) scores. Therefore, the right MFC and right IFG were selected as regions of interest for RSFC analysis. PI patients had weakened RSFC between the right inferior parietal gyrus (IPC) and the right MFC compared to the healthy controls and between the left OFC and right IFG. The RSFC between the right MFC and right IPC negatively correlated with SRSS scores. The RSFC between the right IFG and left OFC negatively corr...Continue Reading

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Software Mentioned

VBM8
Matlab2011a
fMRI
SPM8
SPSS
REST1
SAS
Statistical Parametric Mapping 8 SPM8
FMRIB Software Library ( FSL )
Resting State fMRI Data Analysis Toolkit ( REST1

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