Functional connectivity analysis of fMRI data using parameterized regions-of-interest

NeuroImage
Wouter D WeedaHilde M Huizenga

Abstract

Connectivity analysis of fMRI data requires correct specification of regions-of-interest (ROIs). Selection of ROIs based on outcomes of a GLM analysis may be hindered by conservativeness of the multiple comparison correction, while selection based on brain anatomy may be biased due to inconsistent structure-to-function mapping. To alleviate these problems we propose a method to define functional ROIs without the need for a stringent multiple comparison correction. We extend a flexible framework for fMRI analysis (Activated Region Fitting, Weeda et al. 2009) to connectivity analysis of fMRI data. This method describes an entire fMRI data volume by regions of activation defined by a limited number of parameters. Therefore a less stringent multiple comparison procedure is required. The regions of activation from this analysis can be directly used to estimate functional connectivity. Simulations show that Activated Region Fitting can recover the connectivity of brain regions. An application to real data of a Go/No-Go experiment highlights the advantages of the method.

References

Mar 22, 2002·NeuroImage·Christopher R GenoveseThomas Nichols
Sep 2, 2003·NeuroImage·K J FristonW Penny
Oct 19, 2004·NeuroImage·Jesse RissmanMark D'Esposito
Oct 27, 2004·NeuroImage·Stephen M SmithPaul M Matthews
Aug 10, 2005·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Michael Eichler
Apr 26, 2006·NeuroImage·K J FristonR N Henson
Nov 6, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Adam R AronVeit Stuphorn
Oct 7, 2008·Neuroscience and Biobehavioral Reviews·Christopher D ChambersMark A Bellgrove
Sep 15, 2009·NeuroImage·J D RamseyC Glymour

❮ Previous
Next ❯

Citations

Apr 29, 2014·Neurobiology of Aging·Jonas PerssonLars Nyberg

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Related Papers

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
B BiswalJ S Hyde
Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
R Cameron CraddockHelen S Mayberg
© 2021 Meta ULC. All rights reserved