Functional connectivity and brain networks in schizophrenia.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Mary-Ellen LynallEd Bullmore

Abstract

Schizophrenia has often been conceived as a disorder of connectivity between components of large-scale brain networks. We tested this hypothesis by measuring aspects of both functional connectivity and functional network topology derived from resting-state fMRI time series acquired at 72 cerebral regions over 17 min from 15 healthy volunteers (14 male, 1 female) and 12 people diagnosed with schizophrenia (10 male, 2 female). We investigated between-group differences in strength and diversity of functional connectivity in the 0.06-0.125 Hz frequency interval, and some topological properties of undirected graphs constructed from thresholded interregional correlation matrices. In people with schizophrenia, strength of functional connectivity was significantly decreased, whereas diversity of functional connections was increased. Topologically, functional brain networks had reduced clustering and small-worldness, reduced probability of high-degree hubs, and increased robustness in the schizophrenic group. Reduced degree and clustering were locally significant in medial parietal, premotor and cingulate, and right orbitofrontal cortical nodes of functional networks in schizophrenia. Functional connectivity and topological metrics were...Continue Reading

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Citations

Jun 20, 2012·Experimental Brain Research·Brian P KeaneMilton E Strauss
Jul 24, 2012·European Archives of Psychiatry and Clinical Neuroscience·Ralf TepestKai Vogeley
Oct 18, 2011·Brain Imaging and Behavior·Degang ZhangTianming Liu
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Jan 9, 2013·Brain Connectivity·Chandan J Vaidya, Evan M Gordon
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