Functional connectivity-based subtypes of individuals with and without autism spectrum disorder

Network Neuroscience
Amanda K EassonAnthony R McIntosh

Abstract

Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder, characterized by impairments in social communication and restricted, repetitive behaviors. Neuroimaging studies have shown complex patterns and functional connectivity (FC) in ASD, with no clear consensus on brain-behavior relationships or shared patterns of FC with typically developing controls. Here, we used a dimensional approach to characterize two distinct clusters of FC patterns across both ASD participants and controls using k-means clustering. Using multivariate statistical analyses, a categorical approach was taken to characterize differences in FC between subtypes and between diagnostic groups. One subtype was defined by increased FC within resting-state networks and decreased FC across networks compared with the other subtype. A separate FC pattern distinguished ASD from controls, particularly within default mode, cingulo-opercular, sensorimotor, and occipital networks. There was no significant interaction between subtypes and diagnostic groups. Finally, a dimensional analysis of FC patterns with behavioral measures of IQ, social responsiveness, and ASD severity showed unique brain-behavior relations in each subtype and a continuum of brai...Continue Reading

References

Dec 31, 2002·Proceedings of the National Academy of Sciences of the United States of America·Michael D GreiciusVinod Menon
May 14, 2003·Archives of General Psychiatry·John N Constantino, Richard D Todd
Oct 22, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Matthew K BelmonteSara J Webb
Oct 27, 2004·NeuroImage·Anthony Randal McIntosh, Nancy J Lobaugh
Jun 17, 2005·European Child & Adolescent Psychiatry·Michal HrdlickaTomas Urbanek
Jun 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Michael D FoxMarcus E Raichle
Oct 18, 2006·Behavioral and Brain Functions : BBF·Katherine C TurnerRalph-Axel Müller
Dec 18, 2007·NeuroImage·Daniel P Kennedy, Eric Courchesne
Jan 9, 2009·American Journal of Mental Retardation : AJMR·Jeffrey MunsonRobert Abbott
Apr 25, 2009·Brain : a Journal of Neurology·Stewart H MostofskyJames J Pekar
May 5, 2009·NeuroImage·Christopher S MonkCatherine Lord
Jul 27, 2010·NeuroImage·Anjali KrishnanHervé Abdi
Sep 11, 2010·Science·Nico U F DosenbachBradley L Schlaggar
Oct 15, 2010·Cerebral Cortex·Jeffrey S AndersonJanet E Lainhart
Oct 19, 2011·Brain : a Journal of Neurology·Jeffrey S AndersonJanet E Lainhart
Nov 22, 2011·Neuron·Jonathan D PowerSteven E Petersen
Feb 23, 2012·Neuroscience and Biobehavioral Reviews·Marcel Adam JustSashank Varma
Aug 7, 2012·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Stelios GeorgiadesUNKNOWN Pathways in ASD Study Team
Jul 23, 2013·Frontiers in Human Neuroscience·Stephen J GottsAlex Martin
Aug 24, 2013·Frontiers in Human Neuroscience·Lucina Q UddinVinod Menon
Sep 3, 2013·NeuroImage·Jonathan D PowerSteven E Petersen
Oct 29, 2013·NeuroImage·Alexandre GramfortMatti S Hämäläinen
Jan 1, 2012·NeuroImage. Clinical·J D RudieM Dapretto
Nov 19, 2013·Cell Reports·Jeffrey David Rudie, Mirella Dapretto
Jan 17, 2014·Frontiers in Neuroscience·Alexandre GramfortMatti Hämäläinen
Sep 23, 2014·Journal of Autism and Developmental Disorders·Haylie L MillerMatthew W Mosconi
Mar 17, 2015·NeuroImage·Raimon H R PruimChristian F Beckmann
Apr 7, 2015·NeuroImage. Clinical·Jason S Nomi, Lucina Q Uddin
Jul 4, 2015·Human Brain Mapping·Giacomo HandjarasEmiliano Ricciardi
Oct 19, 2016·NeuroImage·Jonathan D PowerAlex Martin

❮ Previous
Next ❯

Citations

Aug 25, 2019·Journal of Autism and Developmental Disorders·Chanaka N KahathuduwaAnn Mastergeorge
Oct 16, 2019·Autism Research : Official Journal of the International Society for Autism Research·Yu LiXiaoxiao Wang
Oct 22, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Tessa M van LeeuwenRob van Lier
Feb 25, 2020·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Danilo BzdokAndre F Marquand
Nov 8, 2020·Translational Psychiatry·Mariam ZabihiUNKNOWN EU-AIMS LEAP Group
Dec 9, 2020·Molecular Autism·Veronica YukMargot J Taylor
Feb 14, 2021·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Lindsay D OliverUNKNOWN SPINS Group
Jun 20, 2020·Biological Psychiatry·Seok-Jun HongAdriana Di Martino
Sep 18, 2020·Developmental Cognitive Neuroscience·Sara Sanchez-Alonso, Richard N Aslin
Mar 4, 2021·European Psychiatry : the Journal of the Association of European Psychiatrists·Yvonne SchröderIgor Nenadić
May 8, 2021·Clinical Psychology Review·Joost A Agelink van RentergemHilde M Geurts
Jun 10, 2021·Brain Connectivity·Alexandra M ReardonXiaoping P Hu

❮ Previous
Next ❯

Software Mentioned

Power
ABIDE
MNE
MATLAB
PLS
Autism Brain Imaging Data Exchange ( ABIDE )
ICA
AROMA
Connectome Computation System ( CCS )

Related Concepts

Related Feeds

Autism

Autism spectrum disorder is associated with challenges with social skills, repetitive behaviors, and often accompanied by sensory sensitivities and medical issues. Here is the latest research on autism.