Functional connectivity between prefrontal cortex and subgenual cingulate predicts antidepressant effects of ketamine

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
Matti GärtnerMilan Scheidegger

Abstract

Converging evidence suggests that a single sub-anesthetic dose of ketamine can produce strong and rapid antidepressant effects in patients that do not respond to standard treatment. Despite a considerable amount of research investigating ketamine's mechanisms of action, the exact neuronal targets conveying the antidepressant effects have not been identified yet. Preclinical studies suggest that molecular changes induced by ketamine bring forward large-scale network reconfigurations that might relate to ketamine's antidepressant properties. In this prospective two-site study we measured resting state fMRI in 24 depressed patients prior to, and 24 h after a single sub-anesthetic dose of ketamine. We analyzed functional connectivity (FC) at baseline and after ketamine and focused our analysis on baseline FC and FC changes directly linked to symptom reduction in order to identify neuronal targets that predict individual clinical responses to ketamine. Our results show that FC increases after ketamine between right lateral prefrontal cortex (PFC) and subgenual anterior cingulate cortex (sgACC) are positively linked to treatment response. Furthermore, low baseline FC between these regions predicts treatment outcome. We conclude that ...Continue Reading

Citations

Dec 6, 2019·Molecular Psychiatry·Rebecca B Price, Ronald Duman
May 7, 2020·Reviews in the Neurosciences·Rebecca McMillan, Suresh D Muthukumaraswamy
Jul 30, 2020·The International Journal of Neuropsychopharmacology·Mu-Hong ChenTung-Ping Su
Jul 14, 2020·Frontiers in Psychiatry·Allison C NugentCarlos A Zarate
Dec 15, 2020·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Ana Herrera-MelendezMatti Gärtner
Feb 12, 2021·International Review of Psychiatry·Luke A Jelen, James M Stone
Apr 3, 2020·Journal of the Neurological Sciences·Molly C KalmoeCharles R Conway
Sep 10, 2020·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Megha M VasavadaAmber M Leaver
Nov 30, 2020·The International Journal of Neuropsychopharmacology·Ana Maria Rivas-GrajalesSanjay J Mathew
May 14, 2021·Neuroscience and Biobehavioral Reviews·Laith AlexanderAllan H Young
May 18, 2021·Frontiers in Neuroscience·Ezio CarboniAntonello Novelli
Aug 15, 2021·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Francesc Artigas
Jan 13, 2022·European Archives of Psychiatry and Clinical Neuroscience·Matti GärtnerSimone Grimm

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