Functional Connectivity Changes in Systemic Lupus Erythematosus: A Resting-State Study

Brain Connectivity
Jessika NystedtTor O Strandberg

Abstract

To investigate resting-state functional connectivity of lupus patients and associated subgroups according to the ACR NPSLE case definitions (ACR ad hoc). In addition, we investigated whether or not the observed alterations correlated with disease duration, the systemic lupus erythematosus (SLE)-Disease Activity Index-2000 (SLEDAI-2k), and Systemic Lupus International Collaborating Clinical/ACR organ damage index (SDI)-scores. Anatomical 3T magnetic resonance imaging (MRI) and resting-state functional MRI were performed in 61 female lupus patients (mean age = 37.0 years, range = 18.2-52.0 years) and 20 gender- and age-matched controls (mean age = 36.2 years, range = 23.3-52.2 years) in conjunction with clinical examination and laboratory testing. Whole-brain voxelwise functional connectivity analysis with permutation testing was performed to extract network components that differed in lupus patients relative to healthy controls (HCs). Lupus patients exhibited both inter- and intranetwork hypo- and hyperconnectivity involving several crucial networks. We found reduced connectivity within the default mode network (DMN), the central executive network (CEN), and in-between the DMN and CEN in lupus patients. Increased connectivity wa...Continue Reading

References

Apr 1, 1979·The British Journal of Psychiatry : the Journal of Mental Science·S A Montgomery, M Asberg
Nov 1, 1982·Arthritis and Rheumatism·E M TanR J Winchester
Mar 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·K J FristonR Turner
Jun 1, 1996·Computers and Biomedical Research, an International Journal·R W Cox
Dec 30, 2006·Arthritis and Rheumatism·J G HanlyUNKNOWN Systemic Lupus International Collaborating Clinics
Mar 3, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·William W SeeleyMichael D Greicius
Mar 16, 2007·Medical Image Computing and Computer-assisted Intervention : MICCAI·Günther GrabnerD Louis Collins
Feb 29, 2008·The New England Journal of Medicine·Anisur Rahman, David A Isenberg
Aug 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Devarajan SridharanVinod Menon
Sep 12, 2009·Journal of Child Neurology·Sujatha KannanDiane Chugani
Nov 3, 2009·Seminars in Arthritis and Rheumatism·Wilmer L SibbittCarlos A Roldan
Nov 20, 2009·IEEE Transactions on Medical Imaging·Stefan KleinJosien P W Pluim
May 12, 2010·Nature Reviews. Rheumatology·George K Bertsias, Dimitrios T Boumpas
May 25, 2010·Trends in Cognitive Sciences·Steven L Bressler, Vinod Menon
Jun 10, 2010·Behavioral Neuroscience·Matteo PardiniLuca Roccatagliata
Jul 6, 2010·NeuroImage·Andrew ZaleskyEdward T Bullmore
Oct 23, 2010·Seminars in Arthritis and Rheumatism·Avraham UntermanGisele Zandman-Goddard
Sep 13, 2011·Trends in Cognitive Sciences·Vinod Menon
Oct 8, 2011·NeuroImage·Mark JenkinsonStephen M Smith
Oct 11, 2011·NeuroImage·Hongjian He, Thomas T Liu
Dec 2, 2011·The New England Journal of Medicine·George C Tsokos
Sep 3, 2013·NeuroImage·Jonathan D PowerSteven E Petersen
Nov 20, 2013·Proceedings of the National Academy of Sciences of the United States of America·Ashley C ChenAmit Etkin
Apr 18, 2014·Multiple Sclerosis : Clinical and Laboratory Research·C GobbiM Filippi
May 13, 2014·Frontiers in Neuroinformatics·Brian B AvantsJames C Gee
Jun 3, 2014·Lancet·Larissa LisnevskaiaDavid Isenberg
Aug 28, 2014·NeuroImage. Clinical·Tobias Schmidt-WilckePia C Sundgren
Aug 9, 2016·Psychiatry Research. Neuroimaging·Rui YangHu Cheng

❮ Previous
Next ❯

Citations

Jan 3, 2020·Current Opinion in Rheumatology·Erica MooreChaim Putterman
Apr 10, 2021·Journal of the Neurological Sciences·John G Hanly, Murat Inanç

❮ Previous
Next ❯

Software Mentioned

FMRIB software ( FSL )
Advanced Normalization Tools ( ANTs )
Analysis of Functional NeuroImage ( AFNI )
NPSLE
SPSS

Related Concepts

Related Feeds

Brain Imaging of Neural Circuits

Neural circuits are groups of interconnected neurons which carry out specific functions when activated. Imaging these neural circuits allows researches to further elucidate their mechanisms and functions. Follow this feed to stay up to date on brain imaging of neural circuits.

Brain Imaging of Neural Circuits (MDS)

Neural circuits are groups of interconnected neurons which carry out specific functions when activated. Imaging these neural circuits allows researches to further elucidate their mechanisms and functions. Follow this feed to stay up to date on brain imaging of neural circuits.