Functional connectivity changes in the language network during stroke recovery

Annals of Clinical and Translational Neurology
Veena A NairVivek Prabhakaran

Abstract

Several neuroimaging studies have examined language reorganization in stroke patients with aphasia. However, few studies have examined language reorganization in stroke patients without aphasia. Here, we investigated functional connectivity (FC) changes after stroke in the language network using resting-state fMRI and performance on a verbal fluency (VF) task in patients without clinically documented language deficits. Early-stage ischemic stroke patients (N = 26) (average 5 days from onset), 14 of whom were tested at a later stage (average 4.5 months from onset), 26 age-matched healthy control subjects (HCs), and 12 patients with cerebrovascular risk factors (patients at risk, PR) participated in this study. We examined FC of the language network with 23 seed regions based on a previous study. We evaluated patients' behavioral performance on a VF task and correlation between brain resting-state FC (rsFC) and behavior. Compared to HCs, early stroke patients showed significantly decreased rsFC in the language network but no difference with respect to PR. Early stroke patients showed significant differences in performance on the VF task compared to HCs but not PR. Late-stage patients compared to HCs and PR showed no differences i...Continue Reading

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Citations

Dec 5, 2017·Journal of the International Neuropsychological Society : JINS·Nina F DronkersJuliana V Baldo
Oct 14, 2017·Neurocase·Fazlallah AfshangianUNKNOWN BLAS2T (Bilingual Aphasia in Stroke-Study Team)
Jan 27, 2019·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Y YangZ Zhang
Nov 23, 2019·Journal of Speech, Language, and Hearing Research : JSLHR·Swathi KiranJeffrey P Johnson
Nov 3, 2016·Current Opinion in Neurology·Antonello BaldassarreMaurizio Corbetta
Oct 8, 2018·Brain Topography·Jing GuoHuafu Chen
Aug 12, 2020·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Yuan Tao, Brenda Rapp
Apr 21, 2021·Scientific Reports·Michael IorgaTodd B Parrish
Mar 25, 2021·Brain Connectivity·Grigori YourganovChristopher Rorden
Aug 31, 2021·Neural Plasticity·Jinhuan ZhangHaibo Yu
Apr 13, 2020·NeuroImage·Andrew T DeMarco, Peter E Turkeltaub

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