Functional Connectivity in Adult Brain Tumor Patients: A Systematic Review

Brain Connectivity
Michelle E Fox, Tricia Z King

Abstract

Brain tumor (BT) patients often experience reduced cognitive abilities and disrupted adaptive functioning before and after treatment. An innovative approach to understanding the underlying brain networks associated with these outcomes has been to study the brain's functional connectivity (FC), the spatially distributed and temporally correlated activity throughout the brain, and how it can be affected by a tumor. The present review synthesized the extant BT FC literature that utilizes functional magnetic resonance imaging to study FC strength of commonly observed networks during rest and task. A systematic review of English articles using PubMed was conducted. Search terms included brain tumor OR glioma AND functional connectivity, independent component analysis, ICA, psychophysiological interaction, OR PPI. Studies in which participants were diagnosed with BTs as adults that evaluated specific networks of interest using independent component analysis or seed-based component analysis were included. Twenty-five studies met inclusion criteria. BT patients often presented with decreases in FC strength within well-established networks and increases in atypical FC patterns. Network differences were tumor adjacent and distal, and lef...Continue Reading

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Citations

Jan 31, 2021·Neuropsychology Review·Sarah V ClarkTricia Z King
May 6, 2021·Brain Connectivity·Jolanda DerksLinda Douw

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Methods Mentioned

BETA
SMA
SMAs
surgical resection

Software Mentioned

SBCA

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