Functional connectivity measured with magnetoencephalography identifies persons with HIV disease.

Brain Imaging and Behavior
James T BeckerAnto Bagic

Abstract

There is need for a valid and reliable biomarker for HIV Associated Neurocognitive Disorder (HAND). The purpose of the present study was to provide preliminary evidence of the potential utility of neuronal functional connectivity measures obtained using magnetoencephalography (MEG) to identify HIV-associated changes in brain function. Resting state, eyes closed, MEG data from 10 HIV-infected individuals and 8 seronegative controls were analyzed using mutual information (MI) between all pairs of MEG sensors to determine whether there were functional brain networks that distinguished between subject groups based on cognition (global and learning) or on serostatus. Three networks were identified across all subjects, but after permutation testing (at α < .005) only the one related to HIV serostatus was significant. The network included MEG sensors (planar gradiometers) above the right anterior region connecting to sensors above the left posterior region. A mean MI value was calculated across all connections from the anterior to the posterior groupings; that score distinguished between the serostatus groups with only one error (sensitivity = 1.00, specificity = .88 (X ( 2 ...Continue Reading

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Citations

Jun 12, 2013·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Tony W WilsonSusan Swindells
Feb 25, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Ryouhei Ishii, Leonides Canuet
Dec 4, 2013·Journal of Neurovirology·Katherine M BeckerTony W Wilson
Feb 14, 2016·Translational Research : the Journal of Laboratory and Clinical Medicine·Tony W WilsonTimothy J McDermott
Nov 21, 2015·Brain Imaging and Behavior·Emi YamanoYasuyoshi Watanabe
Aug 26, 2015·Brain Imaging and Behavior·Lindsay J HinesUNKNOWN Multicenter AIDS Cohort Study
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Oct 9, 2018·Network Neuroscience·Javier M Buldú, Mason A Porter
Apr 20, 2018·Brain : a Journal of Neurology·Alex I WiesmanTony W Wilson
Nov 10, 2020·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Anto I BagićRichard C Burgess
Aug 11, 2021·NeuroImage. Clinical·Mikki SchantellTony W Wilson

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