Functional connectivity of hippocampal subregions in PTSD: relations with symptoms

BMC Psychiatry
Bailee L MalivoireCandice M Monson

Abstract

Posttraumatic stress disorder (PTSD) is associated with abnormal hippocampal activity; however, the functional connectivity (FC) of the hippocampus with other brain regions in PTSD and its relations with symptoms warrants further attention. We investigated subregional hippocampal FC in PTSD during a resting state compared with a trauma-exposed control (TEC) group. Based on extant research, we targeted the FCs of the anterior and posterior hippocampal subregions with the amygdala, medial prefrontal cortex (mPFC), and the posterior cingulate (PCC). Resting-state functional magnetic resonance images were acquired from 11 individuals with PTSD and 13 trauma-exposed controls. Anterior and posterior hippocampal FC was compared between groups. Within the PTSD and TEC groups, subregional hippocampal FC was correlated with scores on the Clinician-Administered PTSD Scale (CAPS) at time of scan and 4 months post-scan. Those with PTSD had significantly greater FC compared with the TEC group between the left posterior hippocampus and the bilateral PCC (g's > .96). Direct contrasts of the Fisher z-transformed coefficients indicated that the correlations between CAPS scores 4 months post scan and the FC between the left hippocampal head and t...Continue Reading

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Citations

Oct 17, 2019·Annals of the New York Academy of Sciences·Jennifer D RyanZhong-Xu Liu
Jun 23, 2020·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Hui Juan ChenFeng Chen
Jan 21, 2021·Brain Imaging and Behavior·Yann QuidéWissam El-Hage
Sep 4, 2021·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Jacklynn M FitzgeraldChristine L Larson
May 19, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ai-Shan SuJing Zou

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Methods Mentioned

BETA
imaging technique

Software Mentioned

MRIcron
DARTEL
MATLAB
Data Processing & Analysis of Brain Imaging ( DPABI ) toolbox ...
Mask for Region of Interest Analysis ( MARINA )

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