Functional connectivity predictors and mechanisms of cognitive behavioural therapies: A systematic review with recommendations

The Australian and New Zealand Journal of Psychiatry
Liam MasonVeena Kumari

Abstract

While there is now strong evidence that psychological therapies can alter the activity of individual brain regions, their impact on the functional integration between regions has not yet been systematically evaluated. This area is important given that brain dysconnectivity has been implicated across almost all psychiatric disorders. Accordingly, we sought to establish connectivity predictors and mechanisms of effective psychological therapies. We further establish whether connectivity changes represent normalisation of disorder pathophysiology or compensatory changes. We reviewed studies examining structural and functional connectivity longitudinally as either a predictor or outcome variable of successful psychological therapies across psychiatric disorders. Fifteen studies met our inclusion criteria. All but three related to cognitive behavioural therapy. Of these, five assessed resting state, nine probed affective processing and one probed cognitive processing. Twelve studies reported evidence of functional connectivity as a significant predictor or outcome of cognitive behavioural therapy, with prefronto-limbic circuitry most commonly implicated. Only six studies included healthy participants, limiting direct inferences abou...Continue Reading

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Citations

Jan 13, 2018·The Australian and New Zealand Journal of Psychiatry·Janet D CarterPeter R Joyce
Oct 13, 2018·The Australian and New Zealand Journal of Psychiatry·Andrew GardnerSue Cotton
Apr 17, 2019·Cognitive Neuropsychiatry·R Ryan Darby
Oct 20, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Inema E OrukariJoseph P Culver

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Methods Mentioned

BETA
cognitive behavioural therapy
pharmacotherapy
cognitive behavioural therapies
dialectical

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