DOI: 10.1101/489377Dec 7, 2018Paper

Functional connectomics of affective and psychotic pathology

BioRxiv : the Preprint Server for Biology
Justin T BakerAvram Holmes


Converging evidence indicates that groups of patients with nominally distinct psychiatric diagnoses are not separated by sharp or discontinuous neurobiological boundaries. In healthy populations, individual differences in behavior are reflected in variability across the collective set of functional brain connections (functional connectome). These data suggest that the spectra of transdiagnostic symptom profiles observed in psychiatric patients may map onto detectable patterns of network function. To examine the manner through which neurobiological variation might underlie clinical presentation we obtained functional magnetic resonance imaging (fMRI) data from over 1,000 individuals, including 210 diagnosed with a primary psychotic disorder or affective psychosis (bipolar disorder with psychosis and schizophrenia or schizoaffective disorder), 192 presenting with a primary affective disorder without psychosis (unipolar depression, bipolar disorder without psychosis), and 608 demographically and data-quality matched healthy comparison participants recruited through a large-scale study of brain imaging and genetics. Here, we examine variation in functional connectomes across psychiatric diagnoses, finding striking evidence for dise...Continue Reading

Related Concepts

Affective Disorders, Psychotic
Mental Disorders
Bipolar Disorder
Magnetic Resonance Imaging
Psychotic Disorders
Schizoaffective Disorder
Antipsychotic Agents

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