PMID: 2498939Jan 1, 1989Paper

Functional consequences following methamphetamine-induced neuronal damage

Psychopharmacology
M J De Vito, G C Wagner

Abstract

The functional consequences following methamphetamine-induced neuronal damage were evaluated under several different conditions known to affect the magnitude of the lesion. It was found that methamphetamine (6.25 mg/kg administered SC, four times at 2-h intervals) caused long-lasting depletions of striatal dopamine and serotonin and that pretreatment with the antioxidant, ascorbic acid (100 mg/kg), attenuated these depletions, whereas pretreatment with the superoxide dismutase inhibitor diethyldithiocarbamate (200 mg/kg) exacerbated these depletions. The dopamine depletions resulting from the repeated administration of methamphetamine under these various conditions did not result in any alteration in the consumption of a sweetened-condensed milk solution under baseline conditions. However, when these lesioned animals were challenged with acutely administered methamphetamine, it was observed that there was an altered sensitivity to the milk intake decreasing effects of this compound. That is, the degree to which the acutely administered methamphetamine reduced the intake of sweetened-condensed milk was highly correlated with the magnitude of the methamphetamine-induced dopamine and serotonin depletions. These observations suppor...Continue Reading

References

Sep 1, 1979·Drug and Alcohol Dependence·G C WagnerC R Schuster
Apr 1, 1981·Pharmacology, Biochemistry, and Behavior·S E BittnerL S Seiden
Sep 1, 1980·Pharmacology, Biochemistry, and Behavior·J B LucotL S Seiden

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Citations

Jan 1, 1994·Journal of Neural Transmission. Parkinson's Disease and Dementia Section·Y L Yu, G C Wagner
Jul 1, 1992·Pharmacology, Biochemistry, and Behavior·T YamamuraH Ouchi
Nov 15, 1995·Toxicology Letters·V D'AlmeidaE A Carlini
Aug 23, 2001·Brain Research. Brain Research Reviews·C DavidsonE H Ellinwood
Jan 14, 1998·Brain Research. Developmental Brain Research·G D CapponC V Vorhees
Jul 3, 1999·Progress in Neuro-psychopharmacology & Biological Psychiatry·C S MyersG C Wagner
Jul 21, 1998·Annals of the New York Academy of Sciences·A StadlinY K Szeto
Jan 1, 1992·Journal of Perinatal Medicine·M Thordstein, U A Nilsson
May 5, 1998·Molecular and Chemical Neuropathology·C S MyersG C Wagner
May 1, 1998·Annals of the New York Academy of Sciences·Alfreda StadlinY K Szeto

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