Functional consequences of noncognate interactions between CD4+ memory T lymphocytes and the endothelium

The Journal of Immunology : Official Journal of the American Association of Immunologists
Lutz-Peter BergFederica M Marelli-Berg

Abstract

The recruitment of Ag-specific T cells to sites of inflammation is a crucial step in immune surveillance. Although the molecular interactions controlling T cell extravasation are relatively well characterized, the effects of these events on T cell function are still poorly understood. Using an in vitro model of transendothelial migration of human CD4(+) memory T cells, we have investigated the molecular and functional changes induced in T cells that come into contact with the endothelium. First, we show that transendothelial migration is precluded by signals that lead to T cell division. In addition, activation of the transcription factor AP-1, without induction of NF-kappaB, is observed in T cells after noncognate interactions with endothelial cells (EC), a pattern of transcriptional regulation different from that observed in dividing T cells. Up-regulation of certain adhesion (CD11a, CD49d), activation (CD69), and costimulatory (CD86) receptors accompany these transcriptional events. Most importantly, recently migrated T cells display a faster rate of migration when reseeded onto an EC monolayer. Finally, T cells become hyperresponsive to antigenic challenge after noncognate interactions with the endothelium. These effects ap...Continue Reading

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Citations

Aug 20, 2008·Nature Immunology·Peter Friedl, Bettina Weigelin
Apr 18, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Shishir ShettyDavid H Adams
Jul 11, 2006·Immunological Reviews·Brigitta StockingerGeorge Kassiotis
May 5, 2007·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·George AvraamidesFederica M Marelli-Berg
Mar 6, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·G EineckeP F Halloran
Dec 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·George Kassiotis, Brigitta Stockinger
Nov 18, 2003·Immunological Reviews·Anna Valujskikh, Fadi G Lakkis
Mar 5, 2005·Trends in Immunology·Sussan Nourshargh, Federica M Marelli-Berg
Oct 28, 2011·Trends in Immunology·Jordan S Pober, George Tellides

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