Functional consequences of the somatopause and its treatment

Endocrine
A R HoffmanR Marcus

Abstract

The decline in the function of the growth hormone-releasing hormone, growth hormone, insulin-like growth factor (GHRH-GH-IGF) axis has been termed the somatopause. Many of the catabolic sequelae seen in normal aging has been attributed to this decrease in circulating GH and IGF-I. In order to provide hormone replacement therapy for the somatopause, elderly subjects have been treated with GH, IGF-I, or both hormones together. Whereas numerous beneficial effects on body composition, strength, and quality of life have been reported in some studies, other studies have reported only marginal functional improvements. Moreover, it is clear that both hormones can cause significant morbidity.

References

Dec 1, 1992·The Journal of Clinical Investigation·P D ZenobiE R Froesch
Jul 1, 1992·The Journal of Clinical Endocrinology and Metabolism·D R ClemmonsL E Underwood
Aug 1, 1992·The Journal of Clinical Endocrinology and Metabolism·G PykaR Marcus
May 1, 1991·Journal of Applied Physiology·S L CharetteR Marcus
Mar 1, 1991·The American Journal of Physiology·H H VandenburghR Feldstein
Mar 1, 1991·Journal of the American Geriatrics Society·F E KaiserJ E Morley
Feb 1, 1990·The Journal of Clinical Endocrinology and Metabolism·R MarcusB M Sherman
Jan 1, 1990·European Journal of Applied Physiology and Occupational Physiology·R S StaronG A Dudley
Apr 1, 1990·The Journal of Clinical Endocrinology and Metabolism·N MøllerO Schmitz
Jul 5, 1990·The New England Journal of Medicine·D RudmanD E Mattson
Jun 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C Snow-HarterR Marcus
Jun 1, 1989·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·W C BevierR Marcus
Jul 16, 1987·The New England Journal of Medicine·H P GulerE R Froesch
Mar 1, 1988·Journal of Applied Physiology·W R FronteraW J Evans
Jan 1, 1987·Journal of the American Geriatrics Society·R H WhippleP M Amerman
May 1, 1981·The Journal of Clinical Investigation·D RudmanR P Bain
Feb 1, 1994·The Journal of Clinical Endocrinology and Metabolism·S A LiebermanA R Hoffman
Aug 1, 1994·The Journal of Clinical Endocrinology and Metabolism·L HollowayR Marcus
Jun 1, 1995·The Journal of Clinical Endocrinology and Metabolism·J L ThompsonA R Hoffman
Oct 1, 1994·Endocrine Reviews·L SaccàS Fazio
Feb 1, 1994·Metabolism: Clinical and Experimental·H de BoerJ A Schouten
Mar 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·J O JohanssonB A Bengtsson
Dec 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·L J GhironR Marcus

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Citations

Mar 19, 2004·Biology of Reproduction·Varadaraj ChandrashekarAndrzej Bartke
May 23, 1998·Annual Review of Pharmacology and Toxicology·R Marcus, A R Hoffman
Apr 27, 2010·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Marcello MaggioLuigi Ferrucci
Jul 3, 2004·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Andrew R Hoffman, Gian Paolo Ceda
Jul 26, 2005·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Andrew R Hoffman
Sep 1, 2004·The American Journal of Medicine·Licia DentiGian Paolo Ceda
May 24, 2018·European Journal of Endocrinology·I C van NieuwpoortM L Drent
Nov 24, 1999·The Journal of Clinical Endocrinology and Metabolism·A ColaoG Lombardi
Feb 10, 1999·Experimental Gerontology·A BartkeR T Bronson

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