PMID: 11905201Jun 1, 1968Paper

Functional consequences of ultrastructural geometry in "backwards" fluid-transporting epithelia

The Journal of Cell Biology
J M Diamond, W H Bossert

Abstract

Many fluid-transporting epithelia possess dead-end, long, and narrow channels opening in the direction to which fluid is being transported (basal infoldings, lateral intercellular spaces, etc.). These channels have been thought to possess geometrical significance as standing-gradient flow systems, in which active solute transport into the channel makes the channel contents hypertonic and permits water-to-solute coupling. However, some secretory epithelia (choroid plexus, Malpighian tubule, rectal gland, etc.) have "backwards" channels opening in the direction from which fluid is being transported. It is shown that these backwards channels can function as standing-gradient flow systems in which solute transport out of the channel makes the channel contents hypotonic and results in coupled water flow into the channel mouth. The dependence of the transported osmolarity (isotonic or hypertonic) on channel radius, length, and other parameters is calculated for backwards channels for values of these parameters in the physiological range. In addition to backwards channels' being hypotonic rather than hypertonic, they are predicted to differ from "forwards" channels in that some restrictions are imposed by the problem of solute exhaust...Continue Reading

References

Sep 1, 1967·The Journal of General Physiology·J M Tormey, J M Diamond
Sep 1, 1967·The Journal of General Physiology·J M Diamond, W H Bossert
Aug 1, 1963·The Journal of Cell Biology·C W PHILPOTT, D E COPELAND
May 1, 1960·Circulation·K SCHMIDT-NIELSEN

❮ Previous
Next ❯

Citations

May 23, 1973·Zeitschrift für Zellforschung und mikroskopische Anatomie·D J Milne, R A Ellis
Dec 31, 1973·Zeitschrift für Zellforschung und mikroskopische Anatomie·J M Skelding
Jan 1, 1972·Zeitschrift für Zellforschung und mikroskopische Anatomie·W WichardJ H Abel
Mar 11, 1974·Zeitschrift für Zellforschung und mikroskopische Anatomie·P S LakeJ E Ong
Jan 1, 1971·Zeitschrift für Zellforschung und mikroskopische Anatomie·H H Taylor
Dec 31, 1979·The Journal of Membrane Biology·J M Diamond
Dec 1, 1970·The Journal of Membrane Biology·J W Prather, E M Wright
Jan 1, 1982·The Journal of Membrane Biology·J J Lim, H H Ussing
Jan 1, 1983·The Journal of Membrane Biology·J J LimJ Fischbarg
Jan 1, 1984·Lung·I Nathanson, J A Nadel
Jul 8, 2011·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Jonathan M Whittamore
Feb 1, 1977·International Journal for Parasitology·A A BanajaJ Riley
Feb 1, 1985·International Journal for Parasitology·G L Uglem, K J Lee
Sep 1, 1974·Journal of Insect Physiology·J R SauerJ A Hair
Dec 1, 1975·Journal of Insect Physiology·G R Needham, J R Sauer
May 1, 2012·Pflügers Archiv : European journal of physiology·Miguel A RocafullJesús R del Castillo
Jul 1, 1974·The Journal of Experimental Zoology·D R Peterson, R F Loizzi
Sep 1, 1978·The Anatomical Record·D I Osman, L Plöen
Feb 1, 1983·Kidney International·L W WellingV H Gattone
Jan 1, 1971·Progress in Histochemistry and Cytochemistry·U Schmidt, U C Dubach
Jan 1, 1977·Experimental Eye Research·M B Segal, M Pollay

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.