Functional conservation of the apoptotic machinery from coral to man: the diverse and complex Bcl-2 and caspase repertoires of Acropora millepora

BMC Genomics
Aurelie MoyaDavid J Miller

Abstract

Apoptotic cell death is a defining and ubiquitous characteristic of metazoans, but its evolutionary origins are unclear. Although Caenorhabditis and Drosophila played key roles in establishing the molecular bases of apoptosis, it is now clear that cell death pathways of these animals do not reflect ancestral characteristics. Conversely, recent work suggests that the apoptotic networks of cnidarians may be complex and vertebrate-like, hence characterization of the apoptotic complement of representatives of the basal cnidarian class Anthozoa will help us to understand the evolution of the vertebrate apoptotic network. We describe the Bcl-2 and caspase protein repertoires of the coral Acropora millepora, making use of the comprehensive transcriptomic data available for this species. Molecular phylogenetics indicates that some Acropora proteins are orthologs of specific mammalian pro-apoptotic Bcl-2 family members, but the relationships of other Bcl-2 and caspases are unclear. The pro- or anti-apoptotic activities of coral Bcl-2 proteins were investigated by expression in mammalian cells, and the results imply functional conservation of the effector/anti-apoptotic machinery despite limited sequence conservation in the anti-apoptoti...Continue Reading

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Citations

Dec 17, 2016·The ISME Journal·Steven D QuistadForest L Rohwer
Jan 17, 2017·Nature Reviews. Microbiology·Rebecca Vega ThurberAdrienne M S Correa
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Aug 14, 2020·The Journal of Biological Chemistry·Suman ShresthaA Clay Clark

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Datasets Mentioned

BETA
ABX61040.1
KR351289

Methods Mentioned

BETA
transfection
confocal microscopy
environmental stresses
PCR

Software Mentioned

MrBayes
Molecular Operating Environment ( MOE )
LAS AF Lite
PhyML
TMPred
Phobius
DISOPRED3
ProtTest
BlastP
ClustalW

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