Functional correlates of incoordination in patients with spinocerebellar ataxia 1: a preliminary fMRI study

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
Peruvumba Narayan JayakumarDheeraj Kalladka

Abstract

The neural (blood oxygenation level dependent) correlates of motor coordination of both hands were studied in adult right-handed volunteers and patients with spinocerebellar ataxia 1 (SCA1), using functional magnetic resonance imaging (fMRI) of the entire brain. Each experimental condition consisted of five sets of alternate pronation and supination tasks for either hand in a prescribed sequence as the active phase followed by a period of rest. An intricate network consisting of sensorimotor cortex, supplementary motor area (SMA), cingulate motor area (CMA), putamina and cerebellum, was identified when the task was performed in healthy volunteers. However, cerebellar activity was largely absent with additional activity in contralateral cortices and in thalami in patients with SCA1. This apparent decoupling of sensorimotor cortical and cerebellar areas during coordinated movement in patients with SCA1, suggests that cortico-cerebellar loops may be malfunctioning in SCA1.

References

Jul 18, 1974·The New England Journal of Medicine·H YakuraK Itakura
Jan 1, 1980·Neurology·H E NinoE J Yunis
Apr 1, 1994·Archives of Neurology·L JunckD S Markel
Jan 1, 1994·Journal of Neurology, Neurosurgery, and Psychiatry·I E OrmerodW I McDonald
Dec 1, 1996·Experimental Brain Research·M JueptnerR E Passingham
Jan 1, 1997·Journal of the Neurological Sciences·T TaniwakiI Goto
Jan 1, 1997·Human Brain Mapping·K J Friston
Mar 12, 2002·Acta Neurologica Scandinavica·A Chakravarty, S C Mukherjee
Aug 10, 2005·Archives of Neurology·Ullrich WüllnerThomas Klockgether
Feb 2, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Tanja Schmitz-HübschThomas Klockgether

❮ Previous
Next ❯

Citations

Jul 6, 2012·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Mario QuarantelliClaudio Pignata
Apr 27, 2021·Frontiers in Systems Neuroscience·Greta AmoreAntonio Gennaro Nicotera

❮ Previous
Next ❯

Related Concepts

Related Feeds

Ataxias (MDS)

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Ataxia

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.

Ataxias

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on different types of ataxias here.