Abstract
The neural (blood oxygenation level dependent) correlates of motor coordination of both hands were studied in adult right-handed volunteers and patients with spinocerebellar ataxia 1 (SCA1), using functional magnetic resonance imaging (fMRI) of the entire brain. Each experimental condition consisted of five sets of alternate pronation and supination tasks for either hand in a prescribed sequence as the active phase followed by a period of rest. An intricate network consisting of sensorimotor cortex, supplementary motor area (SMA), cingulate motor area (CMA), putamina and cerebellum, was identified when the task was performed in healthy volunteers. However, cerebellar activity was largely absent with additional activity in contralateral cortices and in thalami in patients with SCA1. This apparent decoupling of sensorimotor cortical and cerebellar areas during coordinated movement in patients with SCA1, suggests that cortico-cerebellar loops may be malfunctioning in SCA1.
References
Oct 1, 1975·Neuropsychologia·N R Varney, A L Benton
Oct 1, 1972·Neurology·R D CurrierA C Tipton
Jul 18, 1974·The New England Journal of Medicine·H YakuraK Itakura
Jan 1, 1980·Neurology·H E NinoE J Yunis
Apr 1, 1994·Archives of Neurology·L JunckD S Markel
Jan 1, 1994·Journal of Neurology, Neurosurgery, and Psychiatry·I E OrmerodW I McDonald
Jul 1, 1993·Nature Genetics·H T OrrH Y Zoghbi
Jan 1, 1995·Acta Neuropathologica·Y RobitailleS J Kish
Oct 1, 1996·Brain : a Journal of Neurology·K BürkT Klockgether
Dec 1, 1996·Experimental Brain Research·M JueptnerR E Passingham
Jan 1, 1997·Journal of the Neurological Sciences·T TaniwakiI Goto
Jun 11, 1998·Magnetic Resonance Imaging·J R ReichenbachE M Haacke
Oct 8, 1998·Brain : a Journal of Neurology·T KlockgetherJ Dichgans
Jan 1, 1997·Human Brain Mapping·K J Friston
Aug 25, 1999·NeuroImage·J D SchmahmannM Petrides
Mar 12, 2002·Acta Neurologica Scandinavica·A Chakravarty, S C Mukherjee
Jan 16, 2003·Brain Research. Cognitive Brain Research·Dinesh G NairJ A Scott Kelso
Jun 24, 2004·Archives of Neurology·Kie HonjoMasayasu Matsumoto
Aug 10, 2005·Archives of Neurology·Ullrich WüllnerThomas Klockgether
Feb 2, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Tanja Schmitz-HübschThomas Klockgether
Citations
Jul 26, 2012·The Cerebellum·Stuart CurrieNigel Hoggard
Jul 6, 2012·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Mario QuarantelliClaudio Pignata
Jun 16, 2011·Human Brain Mapping·Andrea GinestroniMario Mascalchi
Oct 28, 2016·Brain Topography·Anna NigriLaura Canafoglia
Apr 27, 2021·Frontiers in Systems Neuroscience·Greta AmoreAntonio Gennaro Nicotera