PMID: 9535552Apr 16, 1998Paper

Functional correlates of nicotine administration: similarity with drugs of abuse

Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte
F E PontieriB Caronti

Abstract

Changes in the local utilization of cerebral glucose resulting from administered drugs acting on the central nervous system can be evaluated quantitatively by the [14C]2-deoxyglucose method. We report the findings obtained by the [14C]2-deoxyglucose method that contribute to understanding the cerebral functional effects of drugs of abuse and discuss in particular the similarities between nicotine and other addictive drugs. A common consequence of the intravenous administration of psychomotor stimulants and opioids in the rat is the increase in glucose utilization in the shell of nucleus accumbens. This functional change is accompanied by increased local extracellular concentrations of dopamine. Altered functional activity and dopamine neurotransmission in the shell of the nucleus accumbens thus represent distinctive neurobiological markers of the addictive properties of several drugs, independently of the specific neurochemical mechanisms of action. It has recently been shown that the intravenous administration of a pulse of nicotine, at single-unit doses corresponding to those that maintain self-administration in the rat, produces neurochemical and metabolic changes in the shell of the nucleus accumbens that closely resemble t...Continue Reading

Citations

Aug 16, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Teresa R FranklinAnna Rose Childress
Feb 17, 2009·Addictive Behaviors·Annette K McClaveAli H Mokdad
Oct 23, 2014·Alcoholism, Clinical and Experimental Research·Rishi SharmaMahesh M Thakkar
Jul 13, 2006·European Journal of Pharmacology·Francesco E PontieriFrancesco Orzi
Jul 3, 2002·Experimental Biology and Medicine·Parimal ChowdhuryPhillip L Rayford

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