Functional coupling of the metabotropic glutamate receptor, InsP3 receptor and L-type Ca2+ channel in mouse CA1 pyramidal cells.

The Journal of Physiology
Hiroyuki K KatoToshiya Manabe

Abstract

Activity-dependent regulation of calcium dynamics in neuronal cells can play significant roles in the modulation of many cellular processes such as intracellular signalling, neuronal activity and synaptic plasticity. Among many calcium influx pathways into neurons, the voltage-dependent calcium channel (VDCC) is the major source of calcium influx, but its modulation by synaptic activity has still been under debate. While the metabotropic glutamate receptor (mGluR) is supposed to modulate L-type VDCCs (L-VDCCs), its reported actions include both facilitation and suppression, probably reflecting the uncertainty of both the molecular targets of the mGluR agonists and the source of the recorded calcium signal in previous reports. In this study, using subtype-specific knockout mice, we have shown that mGluR5 induces facilitation of the depolarization-evoked calcium current. This facilitation was not accompanied by the change in single-channel properties of the VDCC itself; instead, it required the activation of calcium-induced calcium release (CICR) that was triggered by VDCC opening, suggesting that the opening of CICR-coupled cation channels was essential for the facilitation. This facilitation was blocked or reduced by the inhibi...Continue Reading

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Citations

Jul 11, 2014·Brain Structure & Function·Áron KőszeghyBalázs Pál
May 20, 2015·FEBS Letters·Yunhong Huang, Amantha Thathiah
Feb 14, 2017·Nature Neuroscience·Milos M PetrovicJeremy M Henley
Feb 18, 2017·International Journal of Molecular Sciences·Yajin LiaoJinbo Cheng
Apr 6, 2017·The Journal of Physiology·Toshiya Manabe
Nov 21, 2014·Journal of Neurophysiology·Jeffrey A ZahratkaBruce A Bamber
Jun 4, 2020·International Journal of Molecular Sciences·Roberta Gualdani, Philippe Gailly
Jun 3, 2021·International Journal of Molecular Sciences·Alejandro Martín-BelmonteRafael Luján
Jul 11, 2021·Brain Research Bulletin·Sam A Booker, Peter C Kind

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