Apr 28, 2012

Functional coupling of transcription and splicing

Gene
Marta MontesCarlos Suñé

Abstract

The tightly regulated process of precursor messenger RNA (pre-mRNA) alternative splicing is a key mechanism to increase the number and complexity of proteins encoded by the genome. Evidence gathered in recent years has established that transcription and splicing are physically and functionally coupled and that this coupling may be an essential aspect of the regulation of splicing and alternative splicing. Recent advances in our understanding of transcription and of splicing regulation have uncovered the multiple interactions between components from both types of machinery. These interactions help to explain the functional coupling of RNAPII transcription and pre-mRNA alternative splicing for efficient and regulated gene expression at the molecular level. Recent technological advances, in addition to novel cell and molecular biology approaches, have led to the development of new tools for addressing mechanistic questions to achieve an integrated and global understanding of the functional coupling of RNAPII transcription and pre-mRNA alternative splicing. Here, we review major milestones and insights into RNA polymerase II transcription and pre-mRNA alternative splicing as well as new concepts and challenges that have arisen from...Continue Reading

Mentioned in this Paper

Cell Cycle Progression
U1 small ribonucleoprotein antibody
Nested Transcripts
RNA Polymerase II
Pathogenic Aspects
Nuclease Sensitive Element Binding Protein 1
Biochemical Pathway
Positive Transcriptional Elongation Factor B
DNA Methylation [PE]
Pre-mRNA Splicing

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