Functional crosstalk between T cells and monocytes in cancer and atherosclerosis.

Journal of Leukocyte Biology
Lindsey E PadgettClaire E Olingy

Abstract

Monocytes and monocyte-derived cells, including Mϕs and dendritic cells, exhibit a diverse array of phenotypic states that are dictated by their surrounding microenvironment. These cells direct T cell activation and function via cues that range from being immunosuppressive to immunostimulatory. Solid tumors and atherosclerotic plaques represent two pathological niches with distinct immune microenvironments. While monocytes and their progeny possess a phenotypic spectrum found within both disease contexts, most within tumors are pro-tumoral and support evasion of host immune responses by tumor cells. In contrast, monocyte-derived cells within atherosclerotic plaques are usually pro-atherogenic, pro-inflammatory, and predominantly directed against self-antigens. Consequently, cancer immunotherapies strive to enhance the immune response against tumor antigens, whereas atherosclerosis treatments seek to dampen the immune response against lipid antigens. Insights into monocyte-T cell interactions within these niches could thus inform therapeutic strategies for two immunologically distinct diseases. Here, we review monocyte diversity, interactions between monocytes and T cells within tumor and plaque microenvironments, how certain th...Continue Reading

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Citations

Sep 26, 2020·Cellular Microbiology·Jessica B von PeinMatthew J Sweet
Jan 31, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yelixza I AvilaMarina A Dobrovolskaia
Oct 30, 2020·Frontiers in Immunology·Daniella Muallem SchwartzNehal N Mehta
Dec 2, 2020·European Journal of Clinical Investigation·Stefano MinistriniFabrizio Montecucco
Jun 26, 2021·Journal for Immunotherapy of Cancer·Kikkie PoelsTom T P Seijkens

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