Functional CT with an experimental intravascular contrast agent in the assessment of liver vascular physiology

Academic Radiology
Juha HalavaaraG L Wolf

Abstract

We evaluated liver vascular physiology with a functional spiral computed tomography (CT) technique and an intravascular contrast agent. Eleven rabbits were studied by means of continuous 40-second single-section data acquisition after bolus injection of an experimental contrast agent. Sequential images were reconstructed at 200-msec intervals. Aortic, portal and hepatic venous, and liver time-HU curves were obtained. From these, hepatic blood volume and flow, tissue transit times, and arterial and portal contributions to total liver blood supply were assessed. The following measures were obtained: hepatic blood volume fraction, 0.33 +/- 0.03 (mean +/- standard error); total flow, 241.1 mL/min +/- 33.6 per 100 g of tissue (arterial component, 11.3 mL/min +/- 3.0 per 100 g of tissue; portal component, 226.4 mL/min +/- 30.7 per 100 g of tissue); arterial transit time, 8.7 seconds +/- 1.6; portal transit time, 8.7 seconds +/- 1.3; arterial to portal perfusion ratio, 0.06 +/- 0.01; and calculated arterial and portal perfusion indexes, 0.05 +/- 0.01 and 0.95 +/- 0.01, respectively. Functional CT is a promising, high-resolution tomographic imaging technique for evaluating liver perfusion.

References

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Citations

Sep 19, 2003·Academic Radiology·Mika K KapanenAnna-Maija Häkkinen
Nov 3, 2010·Journal of Liposome Research·Werner KrauseKarsten Rupp
Nov 22, 2008·Journal of Hepatology·Susanne BonekampJeanne Clark
Oct 30, 1998·Human Gene Therapy·M PelegrinM Piechaczyk
Mar 20, 2001·Nature Reviews. Genetics·N Somia, I M Verma

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