Functional Decline and Resilience in Older Women Receiving Adjuvant Chemotherapy for Breast Cancer

Journal of the American Geriatrics Society
Arti HurriaHyman Muss

Abstract

To analyze self-reported changes in physical function in older women with breast cancer receiving adjuvant chemotherapy. Secondary analysis of the Cancer and Leukemia Group B (CALGB) 49907 prospective randomized clinical trial. CALGB institutions in the United States. Women aged 65 and older with Stage I to III breast cancer enrolled in CALGB 49907 who had physical function data from before and after receipt of adjuvant chemotherapy (N=256; mean age 71.5, range 65-85). Participants were administered the physical function subscale of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire before chemotherapy, at the end of chemotherapy, and 12 months after chemotherapy initiation. Functional decline was defined as a more than 10-point decrease from baseline at each time point. Resilience was defined as return to within 10 points of baseline. Multivariable regression was used to examine pretreatment characteristics associated with physical function changes. Of 42% of participants who had physical function decline from before to the end of chemotherapy, 47% recovered by 12 months (were resilient). Almost one-third experienced functional decline from before chemotherapy to 12 months later. Pretr...Continue Reading

References

Sep 1, 1992·Journal of Psychosomatic Research·K EllM Hamovitch
Jan 1, 1991·Social Science & Medicine·N Waxler-MorrisonL Kan
Jan 1, 1991·Social Science & Medicine·C D Sherbourne, A L Stewart
Oct 1, 1987·American Journal of Epidemiology·T E SeemanJ Guralnik
Jun 1, 1983·The American Journal of Psychiatry·R KatzmanH Schimmel
Jun 1, 1983·Acta Psychiatrica Scandinavica·A S Zigmond, R P Snaith
Aug 1, 1994·American Journal of Public Health·V MorJ Hiris
Aug 1, 1993·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·M A SprangersN K Aaronson
Aug 15, 1995·Cancer·E MaunsellL Deschênes
Mar 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Candyce H KroenkeIchiro Kawachi
Jul 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Wendy Demark-WahnefriedHarvey J Cohen
May 14, 2009·JAMA : the Journal of the American Medical Association·Miriam C MoreyWendy Demark-Wahnefried
May 15, 2009·The New England Journal of Medicine·Hyman B MussUNKNOWN CALGB Investigators
Sep 24, 2010·Journal of the National Cancer Institute·Dejana BraithwaiteBette J Caan
Feb 8, 2011·Health and Quality of Life Outcomes·Gill WindleJane Noyes
Feb 9, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alice B KornblithHyman B Muss
Sep 25, 2012·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Roser BelmonteMontserrat Ferrer
Dec 13, 2012·Journal of Cancer Survivorship : Research and Practice·Mary SehlPatricia A Ganz
Jun 13, 2013·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Marian A E van Bokhorst-de van der SchuerenMajon Muller
Sep 26, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stéphanie HoppePierre Soubeyran
Feb 27, 2014·Journal of Cancer Survivorship : Research and Practice·Catherine MarinacJohn P Pierce
Jul 22, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Arti HurriaUNKNOWN American Society of Clinical Oncology
Jan 1, 2016·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Heather E WhitsonCathleen S Colón-Emeric
Feb 10, 2016·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Kathryn E WeaverElectra Paskett
May 21, 2016·Journal of Geriatric Oncology·Carolyn J PresleyWendy Demark-Wahnefried
Aug 2, 2016·Journal of Geriatric Oncology·Wei Duan-PorterMiriam C Morey
Oct 21, 2016·Journal of the American Geriatrics Society·Heidi D KlepinStephen B Kritchevsky
Oct 18, 2016·Current Opinion in Clinical Nutrition and Metabolic Care·Angela M Sanford

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Citations

Apr 23, 2019·Journal of the American Geriatrics Society·Heidi D Klepin, Tanya M Wildes
Nov 26, 2019·The British Journal of Nutrition·Mariana Tavares Miranda LimaYara Cristina de Paiva Maia
Aug 15, 2020·Breast Cancer Research and Treatment·David B BartlettGretchen Kimmick
Feb 3, 2021·Journal of Geriatric Oncology·Willeke G van der Plas-KrijgsmanNienke A de Glas
May 28, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mina S SedrakWilliam Dale
Aug 10, 2021·Journal of Geriatric Oncology·Tim A AhlesArti Hurria
Apr 16, 2021·Journal of the National Comprehensive Cancer Network : JNCCN·Kah Poh LohMelisa L Wong
Nov 25, 2021·Breast Cancer Research and Treatment·Brent J SmallUNKNOWN Thinking Living with Cancer C. O. G.-Age Studies

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