Functional decomposition of the human ERG based on the discrete wavelet transform

Journal of Vision
Mathieu GauvinP Lachapelle

Abstract

The morphology of the electroretinogram (ERG) can be altered as a result of normal and pathological processes of the retina. However, given that the ERG is almost solely assessed in terms of its amplitude and timing, defining the shape of the ERG waveform so that subtle, physiologically driven, morphological changes can be systematically and reproducibly detected remains a challenging problem. We examined if the discrete wavelet transform (DWT) could meet this challenge. Normal human photopic ERGs evoked to a broad range of luminance intensities (to yield waveforms of various shapes, amplitudes, and timings) were analyzed using DWT descriptors of the ERG. Luminance-response curves that were generated using the various DWT descriptors revealed distinct (p < 0.05) luminance-dependence patterns, indicating that the stimulus luminance differently modulates the various time-frequency components of the ERG and thus its morphology. The latter represents the first attempt to study the luminance-dependence of ERG descriptors obtained with the DWT. Analyses of ERGs obtained from patients affected with ON or OFF retinal pathway anomalies were also presented. We show here for the first time that distinct time-frequency descriptors can be s...Continue Reading

Citations

Aug 27, 2016·Documenta Ophthalmologica. Advances in Ophthalmology·Hansa KundraJ Jason McAnany
Mar 21, 2020·Veterinary Ophthalmology·Nathaniel Pasmanter, Simon M Petersen-Jones
Jun 27, 2020·Seminars in Ophthalmology·Soroor BehbahaniHamideh Sabbaghi
Jul 9, 2020·Current Opinion in Psychiatry·Stefan JeroticNadja P Maric
Apr 5, 2016·Documenta Ophthalmologica. Advances in Ophthalmology·Mathieu GauvinPierre Lachapelle
Jul 26, 2017·Documenta Ophthalmologica. Advances in Ophthalmology·Jungeun WooPierre Lachapelle
Mar 9, 2019·Documenta Ophthalmologica. Advances in Ophthalmology·Mercedes GauthierPierre Lachapelle
Jun 24, 2018·Documenta Ophthalmologica. Advances in Ophthalmology·Maja SustarAnthony G Robson
Jun 9, 2017·Documenta Ophthalmologica. Advances in Ophthalmology·Livia M BrandaoAnja M Palmowski-Wolfe
Feb 16, 2020·Documenta Ophthalmologica. Advances in Ophthalmology·Allison L DorfmanPierre Lachapelle
Nov 24, 2020·Documenta Ophthalmologica. Advances in Ophthalmology·Hamid AhmadiehSare Safi
Apr 6, 2021·Documenta Ophthalmologica. Advances in Ophthalmology·Nate PasmanterSimon M Petersen-Jones
Sep 10, 2021·Seminars in Ophthalmology·Samiyeh BakhshiNarsis Daftarian
Sep 25, 2021·Documenta Ophthalmologica. Advances in Ophthalmology·Min GaoBalázs Vince Nagy

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