Functional definition and global regulation of Zur, a zinc uptake regulator in a Streptococcus suis serotype 2 strain causing streptococcal toxic shock syndrome.

Journal of Bacteriology
Youjun FengGeorge F Gao

Abstract

Zinc is an essential trace element for all living organisms and plays pivotal roles in various cellular processes. However, an excess of zinc is extremely deleterious to cells. Bacteria have evolved complex machineries (such as efflux/influx systems) to control the concentration at levels appropriate for the maintenance of zinc homeostasis in cells and adaptation to the environment. The Zur (zinc uptake regulator) protein is one of these functional members involved in the precise control of zinc homeostasis. Here we identified a zur homologue designated 310 from Streptococcus suis serotype 2, strain 05ZYH33, a highly invasive isolate causing streptococcal toxic shock syndrome. Biochemical analysis revealed that the protein product of gene 310 exists as a dimer form and carries zinc ions. An isogenic gene replacement mutant of gene 310, the Delta310 mutant, was obtained by homologous recombination. Physiological tests demonstrated that the Delta310 mutant is specifically sensitive to Zn(2+), while functional complementation of the Delta310 mutant can restore its duration capability, suggesting that 310 is a functional member of the Zur family. Two-dimensional electrophoresis indicated that nine proteins in the Delta310 mutant ar...Continue Reading

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Citations

Apr 18, 2009·Critical Care Medicine·Mary K Dahmer, Michael W Quasney
Aug 18, 2009·Journal of Bacteriology·Youjun Feng, John E Cronan
Jun 3, 2009·Microbiology and Molecular Biology Reviews : MMBR·Greg A Somerville, Richard A Proctor
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Dec 19, 2008·BMC Microbiology·Ying GuoQuanming Zou
Feb 18, 2016·Scientific Reports·Liping FengWeicheng Bei
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Jan 15, 2010·Trends in Microbiology·Youjun FengGeorge F Gao
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Apr 12, 2014·Metallomics : Integrated Biometal Science·Sangyong Choi, Amanda J Bird
Jun 30, 2009·Animal Health Research Reviews·Christoph Georg Baums, Peter Valentin-Weigand
Jul 18, 2019·Frontiers in Cellular and Infection Microbiology·Michał ŚmigaTeresa Olczak
Aug 2, 2018·Biochemical Society Transactions·Alevtina MikhaylinaClaudia A Blindauer
Aug 31, 2019·Emerging Microbes & Infections·Chengkun ZhengPingping Zhou
Feb 2, 2021·Archives of Biochemistry and Biophysics·Emma SevillaMaría F Fillat
May 29, 2021·Nucleic Acids Research·Fenmei LiuZhenhua Ming

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