Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs

John L RinnHoward Y Chang


Noncoding RNAs (ncRNA) participate in epigenetic regulation but are poorly understood. Here we characterize the transcriptional landscape of the four human HOX loci at five base pair resolution in 11 anatomic sites and identify 231 HOX ncRNAs that extend known transcribed regions by more than 30 kilobases. HOX ncRNAs are spatially expressed along developmental axes and possess unique sequence motifs, and their expression demarcates broad chromosomal domains of differential histone methylation and RNA polymerase accessibility. We identified a 2.2 kilobase ncRNA residing in the HOXC locus, termed HOTAIR, which represses transcription in trans across 40 kilobases of the HOXD locus. HOTAIR interacts with Polycomb Repressive Complex 2 (PRC2) and is required for PRC2 occupancy and histone H3 lysine-27 trimethylation of HOXD locus. Thus, transcription of ncRNA may demarcate chromosomal domains of gene silencing at a distance; these results have broad implications for gene regulation in development and disease states.


Feb 12, 1998·Proceedings of the National Academy of Sciences of the United States of America·J ZákányDenis Duboule
Sep 19, 1998·Molecular and Cellular Biology·O DenisenkoK Bomsztyk
Sep 26, 2002·Proceedings of the National Academy of Sciences of the United States of America·Howard Y ChangPatrick O Brown
Dec 13, 2002·Proceedings of the National Academy of Sciences of the United States of America·Robert A DrewellEdward B Lewis
Dec 14, 2002·Proceedings of the National Academy of Sciences of the United States of America·Esther BaeRobert A Drewell
Jan 22, 2003·The Journal of Investigative Dermatology·Cheng-Ming Chuong
Feb 26, 2003·Genes & Development·John L RinnMichael Snyder
Mar 22, 2003·Science·Kathrin PlathYi Zhang
Jul 19, 2003·Science·Marie Kmita, Denis Duboule
Jun 18, 2004·Molecular Cell·Hong ZhangDaniel A Haber
Mar 3, 2005·Genes & Development·Sabine SchmittRenato Paro
Jun 9, 2005·Proceedings of the National Academy of Sciences of the United States of America·Matthew G GuentherRichard A Young
Jun 21, 2005·Current Opinion in Structural Biology·Traci M Tanaka Hall
Jul 1, 2005·Nature·Tae Hoon KimBing Ren
Jul 19, 2005·Genes & Development·Emily Bernstein, C David Allis
Sep 6, 2005·Science·Piero CarninciRIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Apr 19, 2006·Genes & Development·Adrian P BrackenKristian Helin
Aug 29, 2006·Nature Structural & Molecular Biology·Daniel H KimJohn J Rossi
Sep 30, 2006·Science·Derek Lemons, William McGinnis
Oct 25, 2006·Nature Reviews. Cancer·Anke Sparmann, Maarten van Lohuizen


Aug 28, 2010·Cellular and Molecular Life Sciences : CMLS·V A Blomen, J Boonstra
Sep 1, 2012·Cellular and Molecular Life Sciences : CMLS·Min Xu, Yin-Yuan Mo
Jul 25, 2013·Cellular and Molecular Life Sciences : CMLS·M KitagawaTatsuya Ohhata
Oct 8, 2008·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Paulo P Amaral, John S Mattick
Sep 4, 2009·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Takashi Nagano, Peter Fraser
Jan 1, 2013·Pediatric Surgery International·Raquel Domingo-FernandezIsabella Bray
Feb 22, 2012·Chromosoma·M Maggie O'Meara, Jeffrey A Simon
Mar 20, 2012·Chromosoma·Martin Leeb, Anton Wutz
Jul 5, 2012·Planta·Cecilia Contreras-CubasAlejandra A Covarrubias
Apr 9, 2008·Development Genes and Evolution·Teresa D ShippyRobin E Denell
Mar 4, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Ioanna BoubaIoannis Georgiou
Mar 2, 2011·Molecules and Cells·Sojin An, Ji-Joon Song
May 10, 2008·Acta Biotheoretica·Richard V Sternberg
Nov 22, 2013·Breast Cancer Research and Treatment·Kristina P SørensenTorben A Kruse
Oct 24, 2013·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Jamila I Horabin
Nov 6, 2013·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Tanmoy Mondal, Chandrasekhar Kanduri
Nov 20, 2013·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Claudia Keller, Marc Bühler
Nov 16, 2013·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Deepak K Singh, Kannanganattu V Prasanth
Nov 16, 2013·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Jae Bok HeoSibum Sung
Nov 20, 2013·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Edwige Hiriart, André Verdel
Nov 28, 2013·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Brian P Chadwick, Kristin C Scott
Nov 13, 2008·Cytotechnology·Shinobu KawamuraKosuke Tashiro
Feb 17, 2010·Journal of Mammary Gland Biology and Neoplasia·Monique RijnkelsEve Devinoy
Feb 22, 2012·Journal of Mammary Gland Biology and Neoplasia·Hai-Long Piao, Li Ma
Mar 10, 2012·Journal of Mammary Gland Biology and Neoplasia·Amy N ShoreJeffrey M Rosen
Sep 6, 2012·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Liang-Ting LinYi-Jang Lee
Oct 5, 2013·Science China. Life Sciences·Wenchuan QiLing Li
Apr 27, 2013·Frontiers of Medicine·Sandy Leung-Kuen AuChun-Ming Wong
Oct 5, 2011·Molecular Neurobiology·Shan Bian, T Sun
Oct 12, 2012·International Journal of Hematology·Goro Sashida, Atsushi Iwama
Apr 27, 2012·Journal of Physiology and Biochemistry·Yong HuangQuan Zou
Jan 6, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Reo MaruyamaYasuhisa Shinomura
Jan 30, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Mantang QiuLin Xu
Jan 19, 2013·Sports Medicine·Tobias EhlertDirk A Moser
Jun 25, 2013·Cancer Letters·Xuefei ShiYong Song
Jun 24, 2010·Cell Stem Cell·Aviva Presser AidenBradley E Bernstein
Oct 24, 2013·Trends in Biochemical Sciences·Hans-Martin HerzAli Shilatifard
Dec 3, 2013·Trends in Biochemical Sciences·Lin YangJeannie T Lee
Jun 5, 2013·Trends in Neurosciences·Janine M LaSalleDag H Yasui
Jan 26, 2011·Expert Reviews in Molecular Medicine·Santiago Uribe-LewisAdele Murrell
Aug 30, 2008·Nature·Anna Petherick
May 23, 2009·Cell Death and Differentiation·A H Lund
Aug 4, 2010·Cell Research·Susan C WuYi Zhang
Feb 16, 2011·Cell Research·Andrew J Bannister, Tony Kouzarides
Jul 13, 2013·Experimental & Molecular Medicine·Seong-Min ParkSeon-Young Kim
May 6, 2010·Heredity·Silvia DambacherGunnar Schotta
May 13, 2010·Heredity·E R Gibney, C M Nolan
Nov 26, 2010·Journal of Human Genetics·Asako AokiToshihiro Tanaka
Mar 27, 2009·Leukemia·T Neff, S A Armstrong
Mar 26, 2010·Nature·Nadine L VastenhouwAlexander F Schier
Jun 11, 2010·Nature·Catherine Dulac
Sep 3, 2010·Nature·Michael KerteszEran Segal
Jan 21, 2011·Nature·Raphaël Margueron, Danny Reinberg
Aug 30, 2011·Nature·Mitchell GuttmanEric S Lander
Oct 15, 2010·Nature Biotechnology·Anna Portela, Manel Esteller
Nov 15, 2011·Nature Biotechnology·Tim R MercerJohn L Rinn
Mar 27, 2012·Nature Biotechnology·Farzaneh ModarresiClaes Wahlestedt
Sep 11, 2010·Nature Biotechnology·Carlo M Croce
Oct 15, 2010·Nature Biotechnology·Helai P Mohammad, Stephen B Baylin
Apr 4, 2013·Nature Cell Biology·Maria J Barrero, Juan Carlos Izpisua Belmonte
Dec 12, 2013·Nature Communications·Je-Hyun YoonMyriam Gorospe
Nov 10, 2013·Nature Medicine·Wai Leong Tam, Robert A Weinberg
Oct 24, 2009·Nature Reviews. Cancer·Adrian P Bracken, Kristian Helin
Apr 2, 2010·Nature Reviews. Cancer·Nilay Shah, Saraswati Sukumar
Jun 1, 2013·Nature Reviews. Drug Discovery·Claes Wahlestedt
Nov 1, 2013·Nature Reviews. Drug Discovery·Hui LingGeorge A Calin
Mar 20, 2010·Nature Reviews. Genetics·Raphaël Margueron, Danny Reinberg
May 19, 2012·Nature Reviews. Genetics·Johan Holmberg, Thomas Perlmann
Nov 13, 2013·Nature Reviews. Genetics·Vicent Pelechano, Lars M Steinmetz
Nov 13, 2013·Nature Reviews. Genetics·Yuri B Schwartz, Vincenzo Pirrotta
Dec 4, 2013·Nature Reviews. Genetics·Alessandro Fatica, Irene Bozzoni
Jan 16, 2009·Nature Reviews. Molecular Cell Biology·Peter Brodersen, Olivier Voinnet
Sep 10, 2009·Nature Reviews. Molecular Cell Biology·Jeffrey A Simon, Robert E Kingston
Nov 24, 2011·Nature Reviews. Molecular Cell Biology·Jeannie T Lee
Oct 10, 2013·Nature Reviews. Molecular Cell Biology·Sarah Geisler, Jeff Coller
Feb 12, 2008·Nature Reviews. Microbiology·David M Knipe, Anna R Cliffe
Jul 21, 2012·Nature Reviews. Neuroscience·Irfan A Qureshi, Mark F Mehler
Jun 23, 2009·Nature Structural & Molecular Biology·Mariano AllóAlberto R Kornblihtt
Jun 15, 2010·Nature Structural & Molecular Biology·Selma El Messaoudi-AubertGordon Peters
Jun 5, 2012·Nature Structural & Molecular Biology·Sònia GuilManel Esteller
Nov 8, 2012·Nature Structural & Molecular Biology·Sònia Guil, Manel Esteller
Mar 7, 2013·Nature Structural & Molecular Biology·Tim R Mercer, John S Mattick
Jun 4, 2013·Nature Structural & Molecular Biology·Zhou DuX Shirley Liu
Oct 8, 2013·Nature Structural & Molecular Biology·Luciano Di Croce, Kristian Helin
Oct 1, 2013·Nature Structural & Molecular Biology·Chen DavidovichThomas R Cech
Oct 22, 2013·Nature Structural & Molecular Biology·Syuzo KanekoRoberto Bonasio
Dec 7, 2013·Nature Structural & Molecular Biology·Loyal A Goff, John L Rinn
Nov 7, 2007·Nature Structural & Molecular Biology·Marc Bühler, Danesh Moazed
May 19, 2011·Molecular BioSystems·Scott T Younger, David R Corey
Jan 11, 2008·Proceedings of the National Academy of Sciences of the United States of America·Tim R MercerJohn S Mattick
Feb 4, 2009·Proceedings of the National Academy of Sciences of the United States of America·Yasnory T F SasakiTetsuro Hirose
Oct 23, 2009·Proceedings of the National Academy of Sciences of the United States of America·Fred Winston
Jun 16, 2010·Proceedings of the National Academy of Sciences of the United States of America·Himabindu RamachandrareddyTimothy W McKeithan
Aug 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Sergio BranciamoreSergei N Rodin
Apr 20, 2011·Proceedings of the National Academy of Sciences of the United States of America·Yoon Jung KimTae Hoon Kim
Jun 29, 2011·Proceedings of the National Academy of Sciences of the United States of America·Sonia SharmaAnjana Rao
Dec 7, 2011·Proceedings of the National Academy of Sciences of the United States of America·Matthew D SimonRobert E Kingston
Aug 15, 2012·Proceedings of the National Academy of Sciences of the United States of America·Qi LiDongyang Huang
Feb 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Jihua DingQifa Zhang
Aug 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Steven L CoonDavid C Klein
Feb 16, 2013·Proceedings of the National Academy of Sciences of the United States of America·Eric WangChristopher R Vakoc
Nov 23, 2010·The Journal of Biological Chemistry·Vasundhra KashyapJoseph M Scandura
Oct 27, 2010·The Journal of Experimental Medicine·Nicolaj Strøyer Christophersen, Kristian Helin
Oct 6, 2010·Antioxidants & Redox Signaling·Anthony R Cyr, Frederick E Domann
Feb 6, 2009·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Guo-Cheng Yuan
May 23, 2012·DNA and Cell Biology·Biao Yan, Zhenhua Wang
May 23, 2013·Omics : a Journal of Integrative Biology·Shahram GolbabapourA Hamid A Hadi
May 27, 2011·Molecular Biology of the Cell·Karen NgAnton Wutz
Oct 17, 2009·Briefings in Functional Genomics & Proteomics·Harm van Bakel, Timothy R Hughes
Sep 23, 2009·Briefings in Functional Genomics & Proteomics·Marcel DingerJohn S Mattick
Dec 25, 2010·Briefings in Functional Genomics·Fabrício F Costa
Jan 25, 2011·Briefings in Functional Genomics·Cameron S OsborneAlice N C Young
Feb 18, 2011·Briefings in Functional Genomics·Paul Delgado-Olguín, Félix Recillas-Targa
Oct 12, 2011·Briefings in Functional Genomics·Rajesh Pandey, Mitali Mukerji
May 28, 2013·Briefings in Functional Genomics·Paulo P AmaralJohn S Mattick
May 12, 2010·Briefings in Bioinformatics·Mikael Huss
Jun 22, 2012·Bioinformatics·Ashwini JeggariErik Larsson
May 12, 2011·Cardiovascular Research·Minna U KaikkonenChristopher K Glass
Mar 10, 2012·Genome Biology and Evolution·Robert S YoungChris P Ponting
Dec 26, 2012·Genome Biology and Evolution·Masatoshi Matsunami, Naruya Saitou
Nov 26, 2013·Genome Biology and Evolution·Raquel López-DíezBegoña Aguado
Oct 8, 2009·Human Molecular Genetics·Gary C HonBing Ren
Aug 24, 2010·Human Molecular Genetics·Maite Huarte, John L Rinn
Apr 9, 2013·Human Molecular Genetics·Debarshi MustafiKrzysztof Palczewski
Oct 3, 2008·Nucleic Acids Research·Marcel DingerJohn S Mattick
Jun 1, 2011·Nucleic Acids Research·Giovanni BussottiCedric Notredame
Apr 12, 2012·Nucleic Acids Research·Victoria A MoranAhmad M Khalil
Jun 26, 2012·Nucleic Acids Research·Celeste Holz-Schietinger, Norbert O Reich
Jul 4, 2012·Nucleic Acids Research·Yuefeng LinBino John
Aug 28, 2012·Nucleic Acids Research·Satish SatiShantanu Sengupta
Apr 6, 2013·Nucleic Acids Research·Qian LiuYin-Yuan Mo
Jul 12, 2013·Nucleic Acids Research·Bokkee EunKarl Pfeifer
Sep 30, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Harini ChakravarthyAngie Rizzino
Dec 2, 2010·Current Opinion in Oncology·Nino Sinčić, Zdenko Herceg
May 8, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Thomas Montavon, Denis Duboule
Jan 16, 2013·TheScientificWorldJournal·Handong MaWeidong Tian
Aug 27, 2010·Cold Spring Harbor Perspectives in Biology·Jeannie T Lee
Jun 25, 2010·Cold Spring Harbor Perspectives in Biology·Xiangting WangMichael G Rosenfeld
Feb 5, 2008·Genes & Development·John L RinnHoward Y Chang
May 3, 2008·Genes & Development·Christine S ChengAlexander Hoffmann
Jul 3, 2009·Genes & Development·Jeremy E WiluszDavid L Spector
Feb 4, 2012·Genes & Development·Markus KretzPaul A Khavari
Dec 23, 2011·Genes & Development·Vikram R Paralkar, Mitchell J Weiss
Feb 4, 2010·Genes & Development·Jordon K WangHoward Y Chang
Feb 4, 2010·Genes & Development·Gang LiDanny Reinberg
Dec 16, 2010·Genes & Development·Sarah J HainerJoseph A Martens
Oct 3, 2012·Genes & Development·Molly G Golden, Jeremy S Dasen
May 18, 2011·Genes & Development·Aimée M Deaton, Adrian P Bird
May 18, 2011·Genes & Development·Melissa L ConerlyStephen J Tapscott
Jun 1, 2013·Genes & Development·Hédia MaamarArjun Raj
Jul 3, 2009·Genes & Development·Jurgi CamblongFrançoise Stutz
May 27, 2008·Genome Research·Vijay K TiwariStephen B Baylin
Jun 20, 2008·Genome Research·Marcel DingerJohn S Mattick
May 22, 2009·Genome Research·Michael HillerPeter F Stadler
Apr 21, 2010·Genome Research·Tanmoy MondalChandrasekhar Kanduri
Dec 24, 2010·Genome Research·W Clay SpencerDavid M Miller
Nov 24, 2011·Genome Research·Andrea PauliAlexander F Schier
Jun 19, 2012·Genome Research·Jin-Wu Nam, David P Bartel
Oct 20, 2012·Genome Research·Carmen M KochWolfgang Wagner
Mar 23, 2013·Genome Research·Pedro MiuraEric C Lai
Nov 22, 2008·Cold Spring Harbor Symposia on Quantitative Biology·M F Cole, R A Young
Apr 20, 2011·Cold Spring Harbor Symposia on Quantitative Biology·Ulf Andersson ØromRamin Shiekhattar
Jul 22, 2010·Development, Growth & Differentiation·Takaaki KonumaAtsushi Iwama
Jun 6, 2009·Science·Natalia Soshnikova, Denis Duboule
Dec 8, 2009·Science·Howard Y Chang
Oct 30, 2010·Science·Roberto BonasioDanny Reinberg
Jul 10, 2010·Science·Miao-Chih TsaiHoward Y Chang
Jul 10, 2010·Science·Matthew G Guenther, Richard A Young
Jan 8, 2011·Science·Franziska Turck, George Coupland
Dec 15, 2012·Science·Jeannie T Lee
Sep 17, 2008·Molecular and Cellular Biology·Nathalie BerteauxEric Adriaenssens
Jul 9, 2008·Biochemistry. Biokhimii︠a︡·S S Ryazansky, V A Gvozdev
Feb 24, 2009·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Hugh W BrockAlexander Mazo
Mar 26, 2009·Annual Review of Biochemistry·Oliver J Rando, Howard Y Chang
Jan 5, 2011·Cancer Research·Miao-Chih TsaiHoward Y Chang
Nov 19, 2011·Cancer Discovery·John R Prensner, Arul M Chinnaiyan
Sep 21, 2010·Circulation·Jochen D MuehlschlegelCABG Genomics Investigators
May 18, 2011·Circulation·Diane E HandyJoseph Loscalzo
May 16, 2013·American Journal of Respiratory Cell and Molecular Biology·Philip ThaiReen Wu
Oct 25, 2012·The Journal of Clinical Investigation·Philipp G MaassSylvia Bähring
May 7, 2013·Blood·Vikram R Paralkar, Mitchell J Weiss
Feb 28, 2009·BMC Bioinformatics·Dandan SongTao Jiang
Nov 16, 2010·BMC Bioinformatics·Jessica L Larson, Guo-Cheng Yuan
May 13, 2010·BMC Developmental Biology·Nicole A RapicavoliSeth Blackshaw
Aug 2, 2011·BMC Developmental Biology·Istvan GyurjánDenis Duboule
Apr 19, 2011·BMC Evolutionary Biology·Sha HeHao Zhu
Jun 20, 2012·BMC Genomics·Hongshi YuMarilyn B Renfree
Jan 18, 2013·BMC Genomics·Paul F BrayIsidore Rigoutsos
Feb 24, 2009·BMC Molecular Biology·Yuliang TanRunsheng Chen
Aug 6, 2008·BMC Molecular Biology·Tiantian LiRunsheng Chen
Apr 15, 2011·Molecular Cancer·Ewan A GibbWan L Lam
May 24, 2011·Molecular Cancer·Masanao TabuseMasahiro Toda
May 23, 2012·Journal of Translational Medicine·Jiri SanaOndrej Slaby
Jun 1, 2013·BMC Biology·Aleksandra E KornienkoFlorian M Pauler
Jul 21, 2011·BMC Biology·A Taylor Bright, Elizabeth A Winzeler
Feb 13, 2013·BMC Medical Genomics·Liran JuanYunlong Liu
May 15, 2013·Journal of Hematology & Oncology·Yan ZhuangBin Shan
Jun 7, 2013·Epigenetics & Chromatin·Swaminathan VenkateshMichaela Smolle
Aug 7, 2013·Epigenetics & Chromatin·Koji TsumagariMelanie Ehrlich
Nov 28, 2013·Epigenetics & Chromatin·Maksim ErokhinDarya Chetverina
Dec 18, 2013·Journal of Experimental & Clinical Cancer Research : CR·Lijuan LiLinbo Gao
Feb 2, 2012·Silence·Aditi Kanhere, Richard G Jenner
May 3, 2013·EvoDevo·Nadezhda I BakalenkoMilana A Kulakova
Nov 7, 2012·Cell & Bioscience·Catherine Lee, Nobuaki Kikyo
Nov 1, 2008·Genome Biology·Debashis SahooSylvia K Plevritis
Apr 1, 2010·Genome Biology·Nathan F CopeChristopher H Eskiw
Jul 14, 2010·Genome Biology·Rebecca A ChodroffChris P Ponting
Oct 26, 2010·Endocrine Reviews·Z HochbergK Albertsson-Wikland
Feb 24, 2009·Development·Amanda Clair NottkeYang Shi
Jun 22, 2012·RNA·Shinichi NakagawaKannanganattu V Prasanth
Dec 4, 2008·RNA·Rory JohnsonLeonard Lipovich
Feb 1, 2008·PLoS Biology·Robert S IllingworthAdrian P Bird
Apr 18, 2008·PLoS Biology·Ian J MajewskiDouglas J Hilton
Dec 5, 2008·PLoS Biology·Vijay K TiwariStephen B Baylin
Jan 7, 2010·PLoS Biology·Sylvain MaennerChristiane Branlant
May 21, 2010·PLoS Biology·Francesca De SantaGioacchino Natoli
Sep 6, 2008·PLoS Genetics·Camilla KwongRobert White
Apr 25, 2009·PLoS Genetics·John S Mattick
Oct 5, 2010·PLoS Genetics·Robert S IllingworthAdrian P Bird
Dec 21, 2010·PLoS Genetics·Eric M MendenhallBradley E Bernstein
Jun 4, 2011·PLoS Genetics·Patrick Schorderet, Denis Duboule
Mar 8, 2012·PLoS Genetics·Nikolaj DietrichKlaus Hansen
Jun 2, 2012·PLoS Genetics·Maheshwar GummallaWelcome Bender
Jul 31, 2012·PLoS Genetics·Claudia KutterAna C Marques
Nov 19, 2013·PLoS Genetics·Patrick SchorderetDenis Duboule
Jun 16, 2012·PloS One·Yunzhe ZhangYuhong Fan
Oct 3, 2012·PloS One·Galina V GlazkoIgor B Rogozin
Mar 7, 2013·Genetics·Johnny T Y KungJeannie T Lee
Dec 28, 2011·The Keio Journal of Medicine·Tetsuro SetoyamaGeorge Adrian Calin
Jan 25, 2012·International Journal of Molecular Sciences·Shahram GolbabapourMaryam Hajrezaei
Feb 9, 2012·International Journal of Molecular Sciences·Letizia Da SaccoAndrea Masotti
Feb 9, 2012·International Journal of Molecular Sciences·Ruth ZarateJesús García-Foncillas
Jan 25, 2013·International Journal of Molecular Sciences·Krisztina SzegediMárta Széll
Jul 16, 2013·International Journal of Molecular Sciences·Alessandro Rosa, Ali H Brivanlou
Jul 28, 2013·International Journal of Molecular Sciences·Andoni Garitano-TrojaolaPuri Fortes
Jul 28, 2013·International Journal of Molecular Sciences·Giovanni BussottiAnton J Enright
Aug 6, 2013·International Journal of Molecular Sciences·Anita Quintal GomesHelena Soares
Aug 24, 2013·International Journal of Molecular Sciences·Federica CaloreMichela Garofalo
Sep 10, 2013·International Journal of Molecular Sciences·Guorui Deng, Guangchao Sui
Sep 17, 2013·International Journal of Molecular Sciences·Jing LiChangning Liu
Oct 3, 2013·International Journal of Molecular Sciences·Daniela ErriquezAlessandra Ferlini
Oct 12, 2013·International Journal of Molecular Sciences·Claudio IaconettiCiro Indolfi
Oct 17, 2013·International Journal of Molecular Sciences·Chiara FenoglioElio Scarpini
Jul 24, 2010·Yi chuan = Hereditas·Jiang-Hong WuJin-Quan Li
Apr 5, 2012·Journal of Visualized Experiments : JoVE·Ci ChuHoward Y Chang
Nov 12, 2013·Chinese Journal of Cancer·Tianzhi HuangShi-Yuan Cheng
Jul 13, 2013·International Journal of Biological Sciences·Zhi-Yuan XuXiang-Dong Cheng
May 31, 2014·World Journal of Gastroenterology : WJG·Wu-Tao LiuJie-Fu Huang
Jan 28, 2014·Nature·Anamaria NecsuleaHenrik Kaessmann
Nov 20, 2013·Leukemia·Raphael Itzykson, Pierre Fenaux
Dec 23, 2010·Future Oncology·Andrea Piunti, Diego Pasini
Mar 1, 2014·Genome Biology·Lin LiGary J Muehlbauer
Jan 8, 2014·Acta Biochimica Et Biophysica Sinica·Xin Huang, Jianhong Zuo
Feb 11, 2014·Best Practice & Research. Clinical Haematology·Raphael ItzyksonPierre Fenaux
Jul 25, 2013·Antioxidants & Redox Signaling·Guohui WanXiongbin Lu
Mar 26, 2014·Trends in Genetics : TIG·Xiaoyang ZhangMathieu Lupien
Sep 13, 2012·Pharmacogenomics·Marina KacevskaMagnus Ingelman-Sundberg
Mar 13, 2014·Trends in Genetics : TIG·Sven Diederichs
Nov 1, 2013·Nucleic Acids Research·Mathieu RousseauJosée Dostie
Jan 28, 2014·Nature Structural & Molecular Biology·Ezgi HacisuleymanJohn L Rinn
Nov 29, 2013·Epigenomics·Silvia DambacherGunnar Schotta
Dec 1, 2009·Epigenomics·Virginie Roure, Frédéric Bantignies
Feb 19, 2014·The Journal of Steroid Biochemistry and Molecular Biology·Arunoday BhanSubhrangsu S Mandal
Oct 31, 2013·Briefings in Functional Genomics·L Carine Stapel, Nadine L Vastenhouw
Nov 20, 2013·Proceedings of the National Academy of Sciences of the United States of America·Rashel V GrindbergRoger S Lasken
Mar 15, 2014·International Journal of Cell Biology·Marianna Nicoletta Rossi, Fabrizio Antonangeli
Jun 8, 2014·Journal of the National Cancer Institute·Pei Y LiuTao Liu
Jun 6, 2012·Annual Review of Biochemistry·John L Rinn, Howard Y Chang
May 3, 2011·Annual Review of Biochemistry·Tamaki Suganuma, Jerry L Workman
Dec 29, 2013·Proceedings of the National Academy of Sciences of the United States of America·Zhonghan LiTariq M Rana
Apr 30, 2014·Nature Reviews. Genetics·Kevin V Morris, John S Mattick
Apr 24, 2014·BioMed Research International·Guangbing LiHaitao Zhao
Mar 13, 2014·International Journal of Hematology·Juan R Alvarez-DominguezHarvey F Lodish
Mar 4, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Mustafa IsinNejat Dalay
Apr 25, 2014·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Jiaming HuangShuzhong Yao
Jan 29, 2014·Proceedings of the National Academy of Sciences of the United States of America·Andrea CeraseNeil Brockdorff
Feb 18, 2014·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Philipp G MaassSylvia Bähring
Aug 30, 2007·Proceedings of the National Academy of Sciences of the United States of America·Sichuan XiKathrin Muegge
Nov 10, 2009·Bioscience, Biotechnology, and Biochemistry·Takuya Kojima, Naoki Takahashi
Jun 21, 2014·Advanced Biomedical Research·Elaheh Emadi-AndaniAli Bidmeshkipour
Sep 22, 2012·Annual Review of Genetics·Chiara Lanzuolo, Valerio Orlando
Jul 11, 2014·Current Opinion in Rheumatology·Halima MoncrieffeSusan D Thompson
Aug 20, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Thomas C RobertsMatthew J A Wood
Apr 1, 2014·The International Journal of Biochemistry & Cell Biology·Amy N Shore, Jeffrey M Rosen
Jul 21, 2014·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Rajeev VikramKhaja Shameem Mohammed Abdul
Mar 29, 2014·Cellular and Molecular Life Sciences : CMLS·Moonmoon DebSamir Kumar Patra
Jul 6, 2014·The International Journal of Biochemistry & Cell Biology·Margherita FrancescattoAlka Saxena
Aug 22, 2012·Annual Review of Genetics·Gioacchino Natoli, Jean-Christophe Andrau
Aug 21, 2013·Science·Andrew Dimond, Peter Fraser
Jan 10, 2012·Annual Review of Immunology·Claudia BossenCornelis Murre
May 21, 2014·The International Journal of Biochemistry & Cell Biology·Jessica N GroenKevin V Morris
May 10, 2011·Cellular and Molecular Neurobiology·Kristan E van der VosXandra O Breakefield
Dec 21, 2013·Nucleic Acids Research·Nicolas PhilippeThérèse Commes
Sep 2, 2014·Médecine sciences : M/S·Eve-Lyne MathieuSalvatore Spicuglia
Oct 3, 2014·Biological Procedures Online·Jinneng Cao
Jul 16, 2014·Trends in Cell Biology·Lingjie Li, Howard Y Chang
Apr 30, 2014·Proceedings of the National Academy of Sciences of the United States of America·Chen-Lin HsiehPhilip W Kantoff
Sep 15, 2014·Trends in Genetics : TIG·Aurélie Kapusta, Cédric Feschotte
Apr 22, 2014·Archives of Gynecology and Obstetrics·Long HuangMin Zheng
Sep 2, 2010·Cell Stem Cell·Lauren E SurfaceLaurie A Boyer
Sep 2, 2010·Cell Stem Cell·Martin Sauvageau, Guy Sauvageau
Jan 3, 2015·Frontiers in Biology·Diana Guallar, Jianlong Wang
Nov 18, 2014·The Journal of Clinical Investigation·Michelle Marques HowarthE Alejandro Sweet-Cordero
Oct 10, 2014·Nature Reviews. Genetics·Anamaria Necsulea, Henrik Kaessmann
Sep 30, 2014·Trends in Molecular Medicine·Maninjay K Atianand, Katherine A Fitzgerald
Nov 19, 2014·Molecular Therapy. Nucleic Acids·Roya Pedram FatemiMohammad Ali Faghihi
Oct 1, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Mohammadreza HajjariYoung Kee Shin
Sep 25, 2014·Annual Review of Genetics·Roberto Bonasio, Ramin Shiekhattar
Feb 22, 2013·Molecular Biology of the Cell·Alexandre Jose Christino QuaresmaJeffrey A Nickerson
Dec 3, 2014·Trends in Cell Biology·Sofia Quinodoz, Mitchell Guttman
Sep 1, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xiaoqiang GuoKaiyuan Deng
Mar 8, 2014·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Midie XuXiang Du
Feb 23, 2013·RNA·Neil Brockdorff
Jul 11, 2014·World Journal of Gastroenterology : WJG·Jun HanZhen-Yu He
Mar 19, 2011·Current Opinion in Cardiology·Apurva V Shirodkar, Philip A Marsden
Feb 9, 2012·Cellular and Molecular Life Sciences : CMLS·Carolina N PerdigotoElena Ezhkova
Mar 15, 2012·Cellular and Molecular Life Sciences : CMLS·Bing-Xue Yan, Jin-Xia Ma
Apr 17, 2013·Cellular and Molecular Life Sciences : CMLS·Ivan ContePaola Bovolenta
Nov 10, 2009·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Randall S Gieni, Michael J Hendzel
May 22, 2009·Neuromolecular Medicine·Rory Johnson, Noel J Buckley
Mar 29, 2008·Science·Paulo P AmaralJohn S Mattick
Feb 18, 2016·Genome Biology·David G HendricksonJohn L Rinn
Jan 20, 2016·Nature Reviews. Genetics·Ekta KhuranaMark Gerstein
Feb 19, 2016·Science Translational Medicine·Janika ViereckThomas Thum
Feb 18, 2016·Molecular Genetics and Genomics : MGG·Ruifang WuQianjin Lu
Feb 18, 2016·Genomics, Proteomics & Bioinformatics·Yiwen Fang, Melissa J Fullwood
Apr 21, 2009·FEBS Letters·Robert S Illingworth, Adrian P Bird
Jan 3, 2016·Experimental Cell Research·Ying-Fei LuJin-fang Zhang
Nov 21, 2015·Nucleic Acids Research·Yi ZhaoRunsheng Chen
Nov 7, 2014·Viruses·Mel CampbellYoshihiro Izumiya
Feb 20, 2008·Expert Review of Proteomics·Clemens BönischSandra B Hake
Oct 5, 2011·The Journal of Cell Biology·Howard Y Chang
Mar 13, 2013·Expert Review of Molecular Diagnostics·Katrien Van RoosbroeckGeorge Adrian Calin
Oct 22, 2014·International Journal of Molecular Sciences·Yanlan YaoLunan Wang
Jul 18, 2015·Genes·Stefania Del PreteValérie Gaudin
Feb 16, 2016·Cellular Signalling·Shanshan SunXuan Zhou
May 9, 2012·Expert Opinion on Drug Discovery·Deeksha BhartiyaVinod Scaria
May 23, 2013·Expert Opinion on Biological Therapy·Nicola AmodioPierfrancesco Tassone
Aug 30, 2014·Expert Opinion on Drug Metabolism & Toxicology·April K MarroneIgor P Pogribny
Dec 25, 2008·Critical Reviews in Biochemistry and Molecular Biology·James A Goodrich, Jennifer F Kugel
May 12, 2011·FEBS Letters·John S Mattick
May 18, 2011·FEBS Letters·Carolina Prezioso, Valerio Orlando
Apr 12, 2011·FEBS Letters·Ngai Cheung, Chi Wai Eric So
Aug 26, 2014·Journal of Molecular and Cellular Cardiology·Samir OunzainThierry Pedrazzini
Feb 11, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Michael SandSchapoor Hessam
Aug 5, 2015·Molecular Medicine Reports·Xin Yu, Zheng Li
Apr 1, 2015·Molecular Medicine Reports·Yu WangPeiling Li
Jan 1, 2015·BMC Systems Biology·Qingyang ZhangJi-Ping Wang
Jan 7, 2015·Journal of Cellular Biochemistry·Mazhar AdliSamir S El-Dahr
Jan 26, 2016·Biochemical and Biophysical Research Communications·Hongwei WuZhenguang Li
Jan 29, 2016·Current Opinion in Genetics & Development·Eric A Alcid, Toshio Tsukiyama
Feb 6, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Jie HuangLinlang Guo
Mar 18, 2016·Current Molecular Biology Reports·Jonathan Christopher DubéJosée Dostie
Feb 3, 2016·Biochemistry·Cigall KadochHeike Keilhack
Sep 25, 2015·Nucleic Acids Research·Stéphanie Maupetit-MéhouasPhilippe Arnaud
Aug 5, 2015·Virus Research·Buhle MoyoPatrick B Arbuthnot
Feb 4, 2016·Journal of the American Society of Nephrology : JASN·Wang ZhengXing-Zhen Chen
Sep 1, 2015·Virus Research·Sara Landeras-Bueno, Juan Ortín
Sep 3, 2014·Journal of Molecular Biology·Danling ZhuCaroline Dean
Jan 31, 2016·Genomics·Yao-zhong DingYong-guang Zhang
Nov 13, 2013·Nucleic Acids Research·Jiao YuanRunsheng Chen
Nov 29, 2013·Nucleic Acids Research·Chaoyong XieYi Zhao
Dec 25, 2015·Journal of Molecular Neuroscience : MN·James D MillsMichael Janitz
Dec 3, 2014·Pharmacology & Therapeutics·Brian S ComerWilliam T Gerthoffer
Dec 18, 2013·Neuroscience·K Schaukowitch, T-K Kim
Jan 8, 2011·Protein & Cell·Amanda Jones, Hengbin Wang
Jan 26, 2016·International Journal of Molecular Sciences·Kun YanAirong Qian
Dec 10, 2015·Epigenetics : Official Journal of the DNA Methylation Society·Lukas VrbaBernard W Futscher
Jul 6, 2014·Nucleic Acids Research·Chen DavidovichThomas R Cech
Mar 10, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Mustafa Isin, Nejat Dalay
Dec 22, 2015·Journal of Biotechnology·Aizhan TastanovaMartin Fussenegger
Jul 3, 2013·Journal of Molecular Biology·John E FrobergJeannie T Lee
Jul 8, 2015·Proceedings of the National Academy of Sciences of the United States of America·Yang WangGucheng Zeng
Dec 11, 2014·Journal of Hematology & Oncology·Gregory LoewenBin Shan
Dec 17, 2014·Proceedings of the National Academy of Sciences of the United States of America·Ramiro GarzonClara D Bloomfield
Sep 10, 2015·Proceedings of the National Academy of Sciences of the United States of America·Gero DooseIngram Iaccarino
Jun 5, 2015·Briefings in Bioinformatics·Fabrizio FerrèManuela Helmer-Citterich
Apr 29, 2015·International Journal of Cardiology·Yidi MaBenzhi Cai
Apr 16, 2013·Analytical Biochemistry·Sivan TzadokIris Dotan
Jan 17, 2016·Seminars in Cell & Developmental Biology·Gregory A Quaife-RyanJames E Hudson
Dec 10, 2015·Journal of Assisted Reproduction and Genetics·Xin HuangHuangguan Dai
Feb 5, 2013·Journal of Molecular Biology·Arunoday BhanSubhrangsu S Mandal
May 7, 2013·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Quan Zhang, Kuan-Teh Jeang
Aug 27, 2015·Experimental Dermatology·Samantha M BeasleyIrene M Pedersen
Nov 28, 2012·Journal of Molecular Biology·Je-Hyun YoonMyriam Gorospe
Oct 31, 2015·Molecular Reproduction and Development·David H TaylorPaul D Soloway
Jul 13, 2012·Trends in Genetics : TIG·Robert IetswaartCaroline Dean
Jan 13, 2015·Science China. Life Sciences·Yin ZhangLiang-Hu Qu
Aug 14, 2009·The Journal of Investigative Dermatology. Symposium Proceedings·Yuji YamaguchiVincent J Hearing
May 24, 2012·Seminars in Nephrology·Alisha JamalPhilip A Marsden
May 1, 2012·Trends in Genetics : TIG·Marco MagistriClaes Wahlestedt
Feb 4, 2012·Trends in Biochemical Sciences·Jennifer F Kugel, James A Goodrich
Dec 20, 2011·Current Opinion in Genetics & Development·Vincenzo Pirrotta, Hua-Bing Li
Dec 14, 2011·Current Opinion in Genetics & Development·Ryan A Flynn, Howard Y Chang
Nov 15, 2011·Current Opinion in Plant Biology·Dong-Hwan Kim, Sibum Sung
Aug 15, 2014·Genome Biology·Nicole M WhiteChristopher A Maher
Nov 23, 2011·Trends in Plant Science·Eun-Deok Kim, Sibum Sung
Feb 18, 2016·Stem Cells International·Shanshan Hu, Ge Shan
May 3, 2013·Protein & Cell·Yeqing Angela Yang, Jindan Yu
Aug 13, 2011·Trends in Genetics : TIG·Ulf Andersson Orom, Ramin Shiekhattar
Jul 29, 2011·Trends in Genetics : TIG·Frédéric Bantignies, Giacomo Cavalli
Nov 19, 2010·The Journal of Investigative Dermatology·Richard L EckertSivaprakasam Balasubramanian
May 24, 2011·Trends in Genetics : TIG·Wu WeiLars M Steinmetz
May 17, 2011·Drug Discovery Today·Christopher A Hamm, Fabrício F Costa
Apr 5, 2011·Biochimica Et Biophysica Acta·Michael GroszmannW James Peacock
Feb 19, 2011·Current Opinion in Genetics & Development·Ulf Andersson Ørom, Ramin Shiekhattar
Feb 25, 2011·Seminars in Cell & Developmental Biology·Chandrasekhar Kanduri
Feb 19, 2011·Current Opinion in Plant Biology·Binglian Zheng, Xuemei Chen
Feb 19, 2011·Journal of Molecular Biology·Philippe Clerc, Philip Avner
Feb 22, 2011·Seminars in Cell & Developmental Biology·Ahmad M Khalil, John L Rinn
Sep 2, 2015·Biochimica Et Biophysica Acta·Amanda J BlytheCharles S Bond
Aug 25, 2015·Biochimica Et Biophysica Acta·Brian S Gloss, Marcel Dinger
Dec 21, 2010·Current Opinion in Plant Biology·Filomena De Lucia, Caroline Dean
Jan 25, 2011·Seminars in Cell & Developmental Biology·Michael B Clark, John S Mattick
Jun 27, 2015·Biochimica Et Biophysica Acta·Sarfraz ShafiqQianwen Sun
Jun 29, 2015·Biochimica Et Biophysica Acta·Shinichi Nakagawa