Functional deterioration from the premorbid period to 2 years after the first episode of psychosis in early-onset psychosis

European Child & Adolescent Psychiatry
Angel Del Rey-MejíasMara Parellada

Abstract

The aim of the study was to analyze changes in functional adjustment from childhood to 2 years after the first episode of psychosis (FEP) in patients with early-onset schizophrenia spectrum disorders (SSD) and affective psychoses (AFP) and a good or intermediate level of premorbid adjustment. We followed 106 adolescents (aged 12-17 years) with FEP for 2 years after recruitment. Premorbid adjustment in childhood was assessed in 98 patients with the childhood subscale of the Cannon-Spoor Premorbid Adjustment Scale (c-PAS). Global functioning was assessed 2 years after the FEP with the Children's Global Assessment Scale (c-GAS) or the Global Assessment of Functioning scale (GAF), as appropriate. Functional deterioration was defined as a downward shift in the level of functional adjustment from childhood to 2 years after the FEP. In patients with good or intermediate premorbid adjustment, functional deterioration was observed in 28.2 % (26.5 % of the AFP group, 29.4 % of the SSD group). Longer duration of untreated psychosis (Beta = 0.01; P = 0.01) and higher symptom severity at the FEP, as measured with the Clinical Global Impression Scale (Beta = 1.12; P = 0.02), significantly predicted the presence of functional deterioration, a...Continue Reading

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Citations

Oct 13, 2016·Early Intervention in Psychiatry·Catherine Shiu-Yin ChongWilliam Tak-Lam Lo
Nov 23, 2017·European Archives of Psychiatry and Clinical Neuroscience·A M Sánchez-TorresUNKNOWN PEPs group
Oct 19, 2017·Schizophrenia Bulletin·Mara ParelladaCelso Arango
Mar 10, 2018·European Child & Adolescent Psychiatry·Covadonga M Díaz-CanejaDolores Moreno
Mar 7, 2020·BMC Psychiatry·Charlotte M TeigsetBjørn Rishovd Rund

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