Functional differences in the backward shifts of CA1 and CA3 place fields in novel and familiar environments.

PloS One
Eric D RothJames J Knierim

Abstract

Insight into the processing dynamics and other neurophysiological properties of different hippocampal subfields is critically important for understanding hippocampal function. In this study, we compared shifts in the center of mass (COM) of CA3 and CA1 place fields in a familiar and completely novel environment. Place fields in CA1 and CA3 were simultaneously recorded as rats ran along a closed loop track in a familiar room followed by a session in a completely novel room. This process was repeated each day over a 4-day period. CA3 place fields shifted backward (opposite to the direction of motion of the rat) only in novel environments. This backward shift gradually diminished across days, as the novel environment became more familiar with repeated exposures. Conversely, CA1 place fields shifted backward across all days in both familiar and novel environments. Prior studies demonstrated that CA1 place fields on average do not exhibit a backward shift during the first exposure to an environment in which the familiar cues are rearranged into a novel configuration, although CA3 place fields showed a strong backward shift. Under the completely novel conditions of the present study, no dissociation was observed between CA3 and CA1 d...Continue Reading

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Citations

Apr 2, 2014·Nature Neuroscience·Joseph D MonacoJames J Knierim
Nov 11, 2014·Nature Neuroscience·David RaposoAnne K Churchland
Aug 10, 2013·Hippocampus·Sheri J Y Mizumori, Yong Sang Jo
Jan 22, 2019·Nature Neuroscience·Heydar Davoudi, David J Foster
Aug 5, 2020·ELife·Oscar C GonzálezMaxim Bazhenov
Oct 27, 2017·Journal of Neurophysiology·Brian J GerekeLaura Lee Colgin
Jan 20, 2018·Nature Communications·Halle R Dimsdale-ZuckerCharan Ranganath
May 22, 2021·Nature Communications·Can DongMark E J Sheffield

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