Functional differentiation within the medial temporal lobe in the rat

Hippocampus
Leonard E JarrardBeverly Bowring

Abstract

The structures that comprise the medial temporal lobe (MTL) have been implicated in learning and memory. The question of primary concern in the present research was whether the group of anatomically related structures (hippocampus, subiculum, presubiculum/parasubiculum, entorhinal cortex, perirhinal/postrhinal cortex) are involved in mediating a similar memory process or whether the individual structures are differentially involved in memory processes and/or in handling various types of information. A series of five experiments were carried out that involved selectively lesioning the main MTL structures and testing each animal on radial-maze tasks and procedures that provided measures of two different memory processes (reference memory, working memory) and the utilization of two kinds of information (spatial, nonspatial). The structures were found to differ functionally, with the hippocampus and the presubiculum/parasubiculum being especially involved in processing spatial information, and the perirhinal/postrhinal cortex having a specific role in remembering information over a brief time period (working memory). Lesions of the entorhinal cortex failed to affect consistently either memory process or type of information handled,...Continue Reading

References

Mar 1, 1992·Behavioral and Neural Biology·J S TaubeC W Cotman
Sep 20, 1991·Science·L R Squire, S Zola-Morgan
Feb 1, 1986·Behavioural Brain Research·J P AggletonJ N Rawlins
Jun 1, 1967·Psychological Bulletin·R J Douglas
Nov 1, 1968·Psychological Bulletin·D P Kimble
Jul 29, 1994·Behavioural Brain Research·K A Wiig, D K Bilkey
Jul 1, 1993·Behavioral and Neural Biology·L E Jarrard
Jan 1, 1997·Annual Review of Psychology·H Eichenbaum
Apr 1, 1997·Current Opinion in Neurobiology·L Nadel, M Moscovitch
Jul 8, 1997·Proceedings of the National Academy of Sciences of the United States of America·E J Golob, J S Taube
Aug 13, 1998·The Journal of Comparative Neurology·R D Burwell, D G Amaral
Jul 27, 2000·Annals of the New York Academy of Sciences·M P WitterT Van Haeften
Jul 27, 2000·Annals of the New York Academy of Sciences·R D Burwell
Jul 27, 2000·Annals of the New York Academy of Sciences·E A MurrayL M Saksida
Nov 21, 2000·Behavioral Neuroscience·D J BucciR D Burwell
Feb 13, 2001·Behavioural Brain Research·K H ChanT L Davidson
Mar 20, 2001·Nature Reviews. Neuroscience·M W Brown, J P Aggleton
Apr 13, 2001·Current Opinion in Neurobiology·E A Murray, B J Richmond
Apr 17, 2001·The Behavioral and Brain Sciences·J P Aggleton, M W Brown
Nov 21, 2001·Experimental Brain Research·D M BannermanM A Good
Nov 24, 2001·Behavioural Brain Research·H Eichenbaum
May 2, 2002·Trends in Cognitive Sciences·James B. Brewer, Abhay Moghekar
Jun 28, 2002·Trends in Neurosciences·Leun J Otten, Michael D Rugg
Jul 9, 2002·Hippocampus·Leonard E Jarrard
Jan 1, 1990·The European Journal of Neuroscience·R. G. M. MorrisL. E. Jarrard

❮ Previous
Next ❯

Citations

Jun 14, 2006·Behavioral Neuroscience·James R Moyer, Thomas H Brown
Feb 10, 2010·Behavioral Neuroscience·Terry L DavidsonLeonard E Jarrard
Jun 2, 2014·Journal of Neuro-oncology·Imola PlangárKatalin Hideghéty
Mar 19, 2014·Physiology & Behavior·Ashley A Martin, Terry L Davidson
Mar 7, 2012·Behavioural Brain Research·Silvia MaioliRoberto Rimondini
Aug 24, 2005·The European Journal of Neuroscience·Anna S Mitchell, John C Dalrymple-Alford
Jun 29, 2007·Hippocampus·David K Bilkey
May 4, 2011·Hippocampus·Leonard E JarrardTerry L Davidson
Apr 11, 2009·Hippocampus·Kara L Agster, Rebecca D Burwell
Jul 1, 2004·Neuroscience and Biobehavioral Reviews·T L Davidson, Leonard E Jarrard
Jan 28, 2006·Neurobiology of Learning and Memory·Eric M Stouffer, Norman M White
Jun 21, 2005·Brain and Cognition·Qazi RahmanFardin Jussab
Oct 5, 2014·Neurobiology of Aging·Henk-Jan WestenengLeonard H van den Berg
Jan 25, 2005·Neuron·Hill-Aina SteffenachEdvard I Moser
Dec 21, 2010·Physiology & Behavior·Scott E Kanoski, Terry L Davidson
Jan 24, 2012·Physiology & Behavior·Scott E Kanoski
Sep 16, 2014·Frontiers in Behavioral Neuroscience·Kally C O'ReillyJanina Ferbinteanu
Dec 30, 2016·Hippocampus·Grethe M OlsenMenno P Witter
Sep 7, 2021·Physiological Reviews·Alan G WattsWolfgang Langhans

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.