Functional disability in early Alzheimer's disease - a validation study of the Italian version of the disability assessment for dementia scale

Dementia and Geriatric Cognitive Disorders
Luc Pieter De VreeseMulticentre Study Group

Abstract

To determine the applicability and psychometric properties of the Italian version of the Disability Assessment of Dementia scale (DAD-I) in a community-residing population with early-stage Alzheimer's disease (AD). The DAD-I was administered to the primary caregivers of 159 patients (mean age +/- SD 77.1 +/- 5.2) with mild AD (mean Mini Mental State Examination, MMSE, +/- SD 23.1 +/- 2.2). The DAD-I showed excellent internal consistency reliability (Cronbach's alpha = 0.92) and good construct validity. The DAD-I score was not significantly associated with gender, education and presumed duration of the illness, and had a low negative correlation with age. The DAD-I score correlated moderately with the traditional Instrumental Activities of Daily Living and Activities of Daily Living scales, respectively, with r = 0.53 and r = 0.54 (p < 0.0001). Relatively low, but statistically significant correlations (r ranging between 0.21 and 0.31) with the MMSE were also found. The DAD-I was found to be a reliable and valid instrument to assess functional disability in community-dwelling Italian subjects with early-stage AD.

References

Jan 1, 1990·Neuroepidemiology·L Gauthier, S Gauthier
Jun 1, 1993·Journal of the American Geriatrics Society·C R GreenK L Davis
Sep 29, 1999·The American Journal of Occupational Therapy : Official Publication of the American Occupational Therapy Association·I GélinasS Gauthier
Aug 29, 2001·Neurology·H FeldmanUNKNOWN Donepezil MSAD Study Investigators Group
Dec 4, 2001·Dementia and Geriatric Cognitive Disorders·A SibleyUNKNOWN Consortium to Investigate Vascular Impairment of Cognition
Apr 23, 2002·JAMA : the Journal of the American Medical Association·Kristine YaffeKenneth E Covinsky
Jun 21, 2002·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Neil AaronsonRuth E Stein
Mar 15, 2003·International Psychogeriatrics·Steven G Potkin
May 22, 2003·Journal of the American Geriatrics Society·Howard FeldmanUNKNOWN Donepezil MSAD Study Investigators Group
Mar 1, 1959·Psychological Bulletin·D T CAMPBELL, D W FISKE
Sep 21, 1963·JAMA : the Journal of the American Medical Association·S KATZM W JAFFE
Nov 18, 2003·International Journal of Geriatric Psychiatry·X KurzA Dresse
Apr 21, 2004·Archives of Neurology·Margaret M SwanbergJeffrey L Cummings
Jul 2, 2004·The New England Journal of Medicine·Jeffrey L Cummings
Sep 8, 2004·International Journal of Geriatric Psychiatry·Guk-Hee SuhAjit Shah
Mar 15, 2005·Alzheimer Disease and Associated Disorders·Howard H FeldmanKoen E L Torfs
May 21, 2005·Drugs & Aging·David J Goldstein, Dennis C Turk
Mar 2, 2006·Drugs & Aging·Carlo CaltagironeUNKNOWN Italian Association of Psychogeriatrics
Jul 4, 2006·Maternal and Child Health Journal·Michelle D OwensFarah M Chowdhury
Apr 28, 2007·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·A AlbericiA Kertesz

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Citations

Jun 9, 2016·International Journal of Geriatric Psychiatry·Emanuela CapotostoErika Borella
Apr 26, 2014·Journal of Geriatric Psychiatry and Neurology·Mukaddes TozluServet Ariogul
May 18, 2010·Alzheimer Disease and Associated Disorders·Valéria Santoro BahiaRicardo Nitrini
Nov 15, 2014·Psychiatry Investigation·Jin Hyeong JhooKi Woong Kim
Oct 19, 2016·Alzheimer Disease and Associated Disorders·Chiara ZucchellaElena Sinforiani
Nov 12, 2015·Medicine·Alicia Sánchez-PérezMiriam Hurtado Pomares
Jan 23, 2018·Dementia & Neuropsychologia·Federica PirasErika Borella
Jan 14, 2021·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Elena CarboneErika Borella

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