Functional distinctness in the exoproteomes of marine Synechococcus

Environmental Microbiology
Joseph A Christie-OlezaDavid J Scanlan

Abstract

The exported protein fraction of an organism may reflect its life strategy and, ultimately, the way it is perceived by the outside world. Bioinformatic prediction of the exported pan-proteome of Prochlorococcus and Synechococcus lineages demonstrated that (i) this fraction of the encoded proteome had a much higher incidence of lineage-specific proteins than the cytosolic fraction (57% and 73% homologue incidence respectively) and (ii) exported proteins are largely uncharacterized to date (54%) compared with proteins from the cytosolic fraction (35%). This suggests that the genomic and functional diversity of these organisms lies largely in the diverse pool of novel functions these organisms export to/through their membranes playing a key role in community diversification, e.g. for niche partitioning or evading predation. Experimental exoproteome analysis of marine Synechococcus showed transport systems for inorganic nutrients, an interesting array of strain-specific exoproteins involved in mutualistic or hostile interactions (i.e. hemolysins, pilins, adhesins), and exoenzymes with a potential mixotrophic goal (i.e. exoproteases and chitinases). We also show how these organisms can remodel their exoproteome, i.e. by increasing t...Continue Reading

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Citations

Jul 5, 2016·Frontiers in Microbiology·Joaquín Giner-LamiaPaulo Oliveira
Dec 15, 2015·Environmental Microbiology·Paulo OliveiraPaula Tamagnini
Sep 30, 2015·Proteomics·Joseph A Christie-Oleza, Jean Armengaud
Jun 27, 2017·Nature Microbiology·Joseph A Christie-OlezaDavid J Scanlan
Dec 2, 2017·Environmental Microbiology·Amandeep KaurJoseph A Christie-Oleza
Jun 9, 2017·MSystems·Maria Agustina Domínguez-MartínJosé Manuel García-Fernández
Sep 4, 2018·Frontiers in Plant Science·Chrysi SergakiPatrick Schäfer
Mar 9, 2018·Physiology and Molecular Biology of Plants : an International Journal of Functional Plant Biology·Neelam DubeySuvendra Nath Bagchi
Nov 12, 2019·Frontiers in Microbiology·Kate L HarveySteven P Djordjevic
Jan 20, 2019·Proceedings of the National Academy of Sciences of the United States of America·Justin M BradleyNick E Le Brun
Mar 27, 2021·Nature Communications·Maria Del Mar Aguilo-FerretjansJoseph A Christie-Oleza
May 28, 2021·Frontiers in Microbiology·Abbrar LabbanXosé Anxelu G Morán
Jul 3, 2021·Microorganisms·Kerrie Ní DhufaighOrla Slattery
Nov 13, 2021·Environmental Microbiology·Steven J BillerSallie W Chisholm

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Datasets Mentioned

BETA
RS9916

Methods Mentioned

BETA
Assay

Software Mentioned

MASCOT
ecretome P
ipo P
BLASTp
ignal P
P attern L ab
Matrix Science
io E dit BLAST
PSORT

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